Abstract
Leukemic transformation (LT) from myelofibrosis has a very poor prognosis with the current treatment strategies. We hypothesized that allogeneic stem cell transplantation (ASCT) can improve outcomes for patients with LT, and reviewed 55 consecutive patients that were treated for myelofibrosis with ASCT at our institution. Fourteen patients (25%) were identified to have LT. Thirteen of these patients received induction chemotherapy and 6 achieved remission at the time of transplant. Conditioning regimen was melphalan (Mel)-based in 9 patients. All patients engrafted and achieved remission after transplant, whereas 4 subsequently relapsed. After a median follow-up of 31 months, 6 patients (49%) survived long term. Although limited by a small number of patients, this study suggests that patients with myelofibrosis and LT may achieve long-term remission after induction chemotherapy and ASCT.
Original language | English (US) |
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Pages (from-to) | 555-559 |
Number of pages | 5 |
Journal | Biology of Blood and Marrow Transplantation |
Volume | 16 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2010 |
Keywords
- Allogeneic stem cell transplantation
- Leukemic transformation
- Myelofibrosis
ASJC Scopus subject areas
- Hematology
- Transplantation