Abstract
A patient whose chronic myelogenous leukemia (CML) was treated with interferon alpha (IFN-α) is described. The disease showed karyotypic evolution during the chronic phase and the later myeloid acceleration. Both of these secondary clonal phenomena responded to IFN-α dose escalation. The case illustrates the dose dependence of CML responses to IFN-α. The phenomenon of clonal evolution is discussed in the context of this patient's disease.
Original language | English (US) |
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Pages (from-to) | 149-151 |
Number of pages | 3 |
Journal | Acta haematologica |
Volume | 83 |
Issue number | 3 |
DOIs | |
State | Published - 1990 |
Keywords
- CML
- Clonal evolution
- Interferon
- Interferon resistance
- Leukemia
ASJC Scopus subject areas
- Hematology