TY - JOUR
T1 - Alteration of the phase and period of a circadian oscillator by a reversible transcription inhibitor
AU - Raju, Uma
AU - Koumenis, Constantinos
AU - Nunez-Regueiro, Marta
AU - Eskin, Arnold
PY - 1991
Y1 - 1991
N2 - A function for transcription in the mechanism of a circadian oscillator was investigated with the reversible transcription inhibitor 5,6-dichloro-1-β- D-ribobenzimidazole (DRB). Two-hour treatments with DRB shifted the phase of the circadian rhythm of the isolated eye of Aplysia, and continuous treatments of DRB lengthened the free running period of this rhythm. Camptothecin, an inhibitor of transcription that is structurally unrelated to DRB, had similar effects on the circadian rhythm. These results suggest that transcription may be part of the circadian oscillating mechanism.
AB - A function for transcription in the mechanism of a circadian oscillator was investigated with the reversible transcription inhibitor 5,6-dichloro-1-β- D-ribobenzimidazole (DRB). Two-hour treatments with DRB shifted the phase of the circadian rhythm of the isolated eye of Aplysia, and continuous treatments of DRB lengthened the free running period of this rhythm. Camptothecin, an inhibitor of transcription that is structurally unrelated to DRB, had similar effects on the circadian rhythm. These results suggest that transcription may be part of the circadian oscillating mechanism.
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U2 - 10.1126/science.1871602
DO - 10.1126/science.1871602
M3 - Article
C2 - 1871602
AN - SCOPUS:0025817881
SN - 0036-8075
VL - 253
SP - 673
EP - 675
JO - Science
JF - Science
IS - 5020
ER -