TY - JOUR
T1 - Altering the Course of Small Cell Lung Cancer
T2 - Targeting Cancer Stem Cells via LSD1 Inhibition
AU - Stewart, C. Allison
AU - Byers, Lauren Averett
N1 - Publisher Copyright:
© 2015 Elsevier Inc..
PY - 2015/7/13
Y1 - 2015/7/13
N2 - In this issue of Cancer Cell, Mohammad etal. describe LSD1, a histone demethylase, as a therapeutic target in SCLC with a unique epigenetic signature to predict drug sensitivity. Inhibition of LSD1 reduces cell proliferation and stem cell maintenance while promoting cell differentiation and reducing tumor growth in preclinical models.
AB - In this issue of Cancer Cell, Mohammad etal. describe LSD1, a histone demethylase, as a therapeutic target in SCLC with a unique epigenetic signature to predict drug sensitivity. Inhibition of LSD1 reduces cell proliferation and stem cell maintenance while promoting cell differentiation and reducing tumor growth in preclinical models.
UR - http://www.scopus.com/inward/record.url?scp=84937485444&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84937485444&partnerID=8YFLogxK
U2 - 10.1016/j.ccell.2015.06.011
DO - 10.1016/j.ccell.2015.06.011
M3 - Short survey
C2 - 26175409
AN - SCOPUS:84937485444
SN - 1535-6108
VL - 28
SP - 4
EP - 6
JO - Cancer cell
JF - Cancer cell
IS - 1
ER -