TY - JOUR
T1 - Alternative splicing of P2RX7 pre-messenger RNA in health and diseases
T2 - Myth or reality?
AU - Benzaquen, Jonathan
AU - Heeke, S.
AU - Janho dit Hreich, Séréna
AU - Douguet, Laetitia
AU - Marquette, Charles Hugo
AU - Hofman, Paul
AU - Vouret-Craviari, Valérie
N1 - Publisher Copyright:
© 2019 Chang Gung University
PY - 2019/6
Y1 - 2019/6
N2 - Alternative splicing (AS) tremendously increases the use of genetic information by generating protein isoforms that differ in protein–protein interactions, catalytic activity and/or subcellular localization. This review is not dedicated to AS in general, but rather we focus our attention on AS of P2RX7 pre-mRNA. Whereas P2RX7 mRNA is expressed by virtually all eukaryotic mammalian cells, the expression of this channel receptor is restrained to certain cells. When expressed at the cell membrane, P2RX7 controls downstream events including release of inflammatory molecules, phagocytosis, cell proliferation and death and metabolic events. Therefore, P2RX7 is an important actor of health and diseases. In this review, we summarize the general mechanisms leading to AS. Further, we recapitulate our current knowledge concerning the functional regions in P2RX7, identified at the genetic or exonic levels, and how AS may affect the expression of these regions. Finally, the potential of P2RX7 splice variants to control the fate of cancer cells is discussed.
AB - Alternative splicing (AS) tremendously increases the use of genetic information by generating protein isoforms that differ in protein–protein interactions, catalytic activity and/or subcellular localization. This review is not dedicated to AS in general, but rather we focus our attention on AS of P2RX7 pre-mRNA. Whereas P2RX7 mRNA is expressed by virtually all eukaryotic mammalian cells, the expression of this channel receptor is restrained to certain cells. When expressed at the cell membrane, P2RX7 controls downstream events including release of inflammatory molecules, phagocytosis, cell proliferation and death and metabolic events. Therefore, P2RX7 is an important actor of health and diseases. In this review, we summarize the general mechanisms leading to AS. Further, we recapitulate our current knowledge concerning the functional regions in P2RX7, identified at the genetic or exonic levels, and how AS may affect the expression of these regions. Finally, the potential of P2RX7 splice variants to control the fate of cancer cells is discussed.
KW - ATP
KW - Onco-immunology
KW - P2X7
KW - Purinergic signaling
UR - http://www.scopus.com/inward/record.url?scp=85068855341&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85068855341&partnerID=8YFLogxK
U2 - 10.1016/j.bj.2019.05.007
DO - 10.1016/j.bj.2019.05.007
M3 - Review article
C2 - 31466708
AN - SCOPUS:85068855341
SN - 2319-4170
VL - 42
SP - 141
EP - 154
JO - Biomedical Journal
JF - Biomedical Journal
IS - 3
ER -