Ameloblastoma: a clinical review and trends in management

Andrew C. McClary; Robert B. West; Ashley C. McClary; Jonathan R. Pollack; Nancy J. Fischbein; Christopher F. Holsinger; John Sunwoo; A. Dimitrios Colevas; Davud Sirjani

doi:10.1007/s00405-015-3631-8

Ameloblastoma: a clinical review and trends in management

Andrew C. McClary, Robert B. West, Ashley C. McClary, Jonathan R. Pollack, Nancy J. Fischbein, Christopher F. Holsinger, John Sunwoo, A. Dimitrios Colevas, Davud Sirjani

Head & Neck Surgery

Research output: Contribution to journal › Review article › peer-review

135 Scopus citations

Abstract

Ameloblastoma is a rare odontogenic neoplasm of the mandible and maxilla, with multiple histologic variants, and high recurrence rates if improperly treated. The current mainstay of treatment is wide local excision with appropriate margins and immediate reconstruction. Here we review the ameloblastoma literature, using the available evidence to highlight the change in management over the past several decades. In addition, we explore the recent molecular characterization of these tumors which may point towards new potential avenues of personalized treatment.

Original language	English (US)
Pages (from-to)	1649-1661
Number of pages	13
Journal	European Archives of Oto-Rhino-Laryngology
Volume	273
Issue number	7
DOIs	https://doi.org/10.1007/s00405-015-3631-8
State	Published - Jul 1 2016

Keywords

Ameloblastoma
BRAF
Clinical review
Genomics
Head and neck surgery
Personalized medicine
SHH

ASJC Scopus subject areas

Otorhinolaryngology

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10.1007/s00405-015-3631-8

Cite this

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title = "Ameloblastoma: a clinical review and trends in management",

abstract = "Ameloblastoma is a rare odontogenic neoplasm of the mandible and maxilla, with multiple histologic variants, and high recurrence rates if improperly treated. The current mainstay of treatment is wide local excision with appropriate margins and immediate reconstruction. Here we review the ameloblastoma literature, using the available evidence to highlight the change in management over the past several decades. In addition, we explore the recent molecular characterization of these tumors which may point towards new potential avenues of personalized treatment.",

keywords = "Ameloblastoma, BRAF, Clinical review, Genomics, Head and neck surgery, Personalized medicine, SHH",

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T2 - a clinical review and trends in management

AU - McClary, Andrew C.

AU - West, Robert B.

AU - McClary, Ashley C.

AU - Pollack, Jonathan R.

AU - Fischbein, Nancy J.

AU - Holsinger, Christopher F.

AU - Sunwoo, John

AU - Colevas, A. Dimitrios

AU - Sirjani, Davud

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AB - Ameloblastoma is a rare odontogenic neoplasm of the mandible and maxilla, with multiple histologic variants, and high recurrence rates if improperly treated. The current mainstay of treatment is wide local excision with appropriate margins and immediate reconstruction. Here we review the ameloblastoma literature, using the available evidence to highlight the change in management over the past several decades. In addition, we explore the recent molecular characterization of these tumors which may point towards new potential avenues of personalized treatment.

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KW - BRAF

KW - Clinical review

KW - Genomics

KW - Head and neck surgery

KW - Personalized medicine

KW - SHH

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Ameloblastoma: a clinical review and trends in management

Abstract

Keywords

ASJC Scopus subject areas

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