Abstract
The nucleotide sequence of the 3'-terminal untranslated region and a portion of the coding region of rat alpha-fetoprotein mRNA has been determined from a cloned double-stranded cDNA. the amino acid sequence of the COOH-terminal portion of alpha-fetoprotein was inferred from the nucleotide sequence and compared to the amino acid sequence of the corresponding portion of rat, bovine, and human albumin. A striking homology in amino acid sequence between alpha-fetoprotein and albumin was observed. These results confirm earlier suggestions that the two proteins are closely related in structure and probably arose from a common ancestral gene.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 8046-8049 |
| Number of pages | 4 |
| Journal | Journal of Biological Chemistry |
| Volume | 255 |
| Issue number | 17 |
| State | Published - Sep 10 1980 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology