Aminoglutethimide-induced hematologic toxicity: Worldwide experience

A. A. Messeih; A. Lipton; R. J. Santen; H. A. Harvey; A. E. Boucher; R. Murray; J. Ragaz; A. U. Buzdar; G. A. Nagel; I. C. Henderson

Aminoglutethimide-induced hematologic toxicity: Worldwide experience

A. A. Messeih, A. Lipton, R. J. Santen, H. A. Harvey, A. E. Boucher, R. Murray, J. Ragaz, A. U. Buzdar, G. A. Nagel, I. C. Henderson

Breast Medical Oncology

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Marked leukopenia and/or thrombocytopenia occurred in 12 of 1333 patients treated with aminoglutethimide (0.9% incidence). Depression of blood cell counts was evident within 7 weeks of starting treatment. No delayed toxicity was encountered. Blood cell counts recovered promptly upon cessation of aminoglutethimide in all but one patient, who died from septicemia and marrow aplasia.

Original language	English (US)
Pages (from-to)	1003-1004
Number of pages	2
Journal	Cancer Treatment Reports
Volume	69
Issue number	9
State	Published - 1985

ASJC Scopus subject areas

Oncology
Cancer Research

Cite this

@article{76f4b8108d7846eea7b1d224b670ef3e,

title = "Aminoglutethimide-induced hematologic toxicity: Worldwide experience",

abstract = "Marked leukopenia and/or thrombocytopenia occurred in 12 of 1333 patients treated with aminoglutethimide (0.9% incidence). Depression of blood cell counts was evident within 7 weeks of starting treatment. No delayed toxicity was encountered. Blood cell counts recovered promptly upon cessation of aminoglutethimide in all but one patient, who died from septicemia and marrow aplasia.",

author = "Messeih, {A. A.} and A. Lipton and Santen, {R. J.} and Harvey, {H. A.} and Boucher, {A. E.} and R. Murray and J. Ragaz and Buzdar, {A. U.} and Nagel, {G. A.} and Henderson, {I. C.}",

year = "1985",

language = "English (US)",

volume = "69",

pages = "1003--1004",

journal = "Cancer Treatment Reports",

issn = "0361-5960",

publisher = "Oxford University Press",

number = "9",

}

TY - JOUR

T1 - Aminoglutethimide-induced hematologic toxicity

T2 - Worldwide experience

AU - Messeih, A. A.

AU - Lipton, A.

AU - Santen, R. J.

AU - Harvey, H. A.

AU - Boucher, A. E.

AU - Murray, R.

AU - Ragaz, J.

AU - Buzdar, A. U.

AU - Nagel, G. A.

AU - Henderson, I. C.

PY - 1985

Y1 - 1985

N2 - Marked leukopenia and/or thrombocytopenia occurred in 12 of 1333 patients treated with aminoglutethimide (0.9% incidence). Depression of blood cell counts was evident within 7 weeks of starting treatment. No delayed toxicity was encountered. Blood cell counts recovered promptly upon cessation of aminoglutethimide in all but one patient, who died from septicemia and marrow aplasia.

AB - Marked leukopenia and/or thrombocytopenia occurred in 12 of 1333 patients treated with aminoglutethimide (0.9% incidence). Depression of blood cell counts was evident within 7 weeks of starting treatment. No delayed toxicity was encountered. Blood cell counts recovered promptly upon cessation of aminoglutethimide in all but one patient, who died from septicemia and marrow aplasia.

UR - http://www.scopus.com/inward/record.url?scp=0022005835&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022005835&partnerID=8YFLogxK

M3 - Article

C2 - 4028032

AN - SCOPUS:0022005835

SN - 0361-5960

VL - 69

SP - 1003

EP - 1004

JO - Cancer Treatment Reports

JF - Cancer Treatment Reports

IS - 9

ER -

Aminoglutethimide-induced hematologic toxicity: Worldwide experience

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this