Abstract
Translocation (8;21) is associated with few typical morphological features and favorable prognosis. All patients of AML and MDS with increased blasts (N=35) according to FAB criteria, presenting (between Jan 2004 to June 2005) to the Department of Hematology, AIIMS were studied. RT-PCR was done for the AML1-ETO fusion transcript in all cases. Overall incidence of AML1-ETO was 28.57% and no correlation was found between AML1-ETO positivity and clinical or hematological parameters except for a direct correlation with absolute blast count (ABC) (a lower ABC in the AML1-ETO positive cases). Interestingly, 1/3 MDS cases were positive for the same fusion transcript and thus, it appears worthwhile to look for AML1-ETO in all cases of MDS with increased blasts. Objective morphological evaluation using a scoring system based on morphological features was not helpful in predicting positivity for AML1-ETO. The effect of this translocation on long-term survival could not be determined by the present study.
Original language | English (US) |
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Pages (from-to) | 652-654 |
Number of pages | 3 |
Journal | Indian Journal of Pathology and Microbiology |
Volume | 50 |
Issue number | 3 |
State | Published - Jul 2007 |
Externally published | Yes |
Keywords
- AML1-ETO
- Acute myeloid leukemia
- RT-PCR
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Microbiology (medical)