Amphiregulin in cancer: New insights for translational medicine

Qixia Xu; Paul Chiao; Yu Sun

doi:10.1016/j.trecan.2016.02.002

Amphiregulin in cancer: New insights for translational medicine

Qixia Xu, Paul Chiao, Yu Sun

Molecular & Cellular Oncology

Research output: Contribution to journal › Short survey › peer-review

28 Scopus citations

Abstract

Although there is a large body of literature regarding amphiregulin (AREG) in human cancer, most knowledge focuses on its cell-autonomous functions in epithelial malignancies. Recent studies revealed that AREG is also present in the tumor microenvironment (TME) and contributes to therapeutic resistance. We discuss emerging concepts of AREG tumor biology and highlight their implications for translational medicine.

Original language	English (US)
Pages (from-to)	111-113
Number of pages	3
Journal	Trends in Cancer
Volume	2
Issue number	3
DOIs	https://doi.org/10.1016/j.trecan.2016.02.002
State	Published - Mar 1 2016

Keywords

amphiregulin
immunosuppression
secretory phenotype
therapeutic resistance
translational medicine
tumor microenvironment

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.trecan.2016.02.002

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title = "Amphiregulin in cancer: New insights for translational medicine",

abstract = "Although there is a large body of literature regarding amphiregulin (AREG) in human cancer, most knowledge focuses on its cell-autonomous functions in epithelial malignancies. Recent studies revealed that AREG is also present in the tumor microenvironment (TME) and contributes to therapeutic resistance. We discuss emerging concepts of AREG tumor biology and highlight their implications for translational medicine.",

keywords = "amphiregulin, immunosuppression, secretory phenotype, therapeutic resistance, translational medicine, tumor microenvironment",

author = "Qixia Xu and Paul Chiao and Yu Sun",

note = "Funding Information: This work was supported by a US Department of Defense (DoD) Prostate Cancer Research Program (PCRP) Idea Development Award (PC111703), the National Natural Science Foundation of China (81472709), and National 1000 Youth Elites Research Program of China to Y.S. Publisher Copyright: {\textcopyright} 2016 Elsevier Inc. All rights reserved.",

year = "2016",

month = mar,

day = "1",

doi = "10.1016/j.trecan.2016.02.002",

language = "English (US)",

volume = "2",

pages = "111--113",

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TY - JOUR

T1 - Amphiregulin in cancer

T2 - New insights for translational medicine

AU - Xu, Qixia

AU - Chiao, Paul

AU - Sun, Yu

N1 - Funding Information: This work was supported by a US Department of Defense (DoD) Prostate Cancer Research Program (PCRP) Idea Development Award (PC111703), the National Natural Science Foundation of China (81472709), and National 1000 Youth Elites Research Program of China to Y.S. Publisher Copyright: © 2016 Elsevier Inc. All rights reserved.

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Although there is a large body of literature regarding amphiregulin (AREG) in human cancer, most knowledge focuses on its cell-autonomous functions in epithelial malignancies. Recent studies revealed that AREG is also present in the tumor microenvironment (TME) and contributes to therapeutic resistance. We discuss emerging concepts of AREG tumor biology and highlight their implications for translational medicine.

AB - Although there is a large body of literature regarding amphiregulin (AREG) in human cancer, most knowledge focuses on its cell-autonomous functions in epithelial malignancies. Recent studies revealed that AREG is also present in the tumor microenvironment (TME) and contributes to therapeutic resistance. We discuss emerging concepts of AREG tumor biology and highlight their implications for translational medicine.

KW - amphiregulin

KW - immunosuppression

KW - secretory phenotype

KW - therapeutic resistance

KW - translational medicine

KW - tumor microenvironment

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U2 - 10.1016/j.trecan.2016.02.002

DO - 10.1016/j.trecan.2016.02.002

M3 - Short survey

C2 - 28741529

AN - SCOPUS:84961794717

SN - 2405-8033

VL - 2

SP - 111

EP - 113

JO - Trends in Cancer

JF - Trends in Cancer

IS - 3

ER -

Amphiregulin in cancer: New insights for translational medicine

Abstract

Keywords

ASJC Scopus subject areas

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