TY - JOUR
T1 - Ampicillin-Sulbactam vs Clindamycin in Head and Neck Oncologic Surgery
T2 - The Need for Gram-negative Coverage
AU - Weber, Randal S.
AU - Raad, Issam
AU - Frankenthaler, Robert
AU - Hankins, Patti
AU - Byers, Robert M.
AU - Guillamondegui, Oscar
AU - Wolf, Pat
AU - Smith, Terry
AU - Goepfert, Helmuth
N1 - Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 1992/11
Y1 - 1992/11
N2 - This study was undertaken to assess whether gram-negative antimicrobial coverage is required in patients undergoing head and neck oncologic surgery. Ampicillin sodium–sulbactam sodium and clindamycin phosphate were compared in a prospective, randomized, parallel, double-blind trial of 212 patients undergoing head and neck procedures involving clean-contaminated wounds. Both antibiotics were given up to 1 hour before surgery and continued at 6-hour intervals after surgery for an additional eight doses. Fourteen infections occurred in the ampicillin-sulbactam–treated group (13.3%) and 29 infections in the clindamycin-treated group (27.1%). From patients receiving clindamycin, 29 gram-negative organisms were isolated, compared with six from those patients receiving ampicillin-sulbactam. This finding supports the need for gram-negative coverage in patients undergoing clean-contaminated head and neck oncologic surgery. (Arch Otolaryngol Head Neck Surg. 1992;118:1159-1163)
AB - This study was undertaken to assess whether gram-negative antimicrobial coverage is required in patients undergoing head and neck oncologic surgery. Ampicillin sodium–sulbactam sodium and clindamycin phosphate were compared in a prospective, randomized, parallel, double-blind trial of 212 patients undergoing head and neck procedures involving clean-contaminated wounds. Both antibiotics were given up to 1 hour before surgery and continued at 6-hour intervals after surgery for an additional eight doses. Fourteen infections occurred in the ampicillin-sulbactam–treated group (13.3%) and 29 infections in the clindamycin-treated group (27.1%). From patients receiving clindamycin, 29 gram-negative organisms were isolated, compared with six from those patients receiving ampicillin-sulbactam. This finding supports the need for gram-negative coverage in patients undergoing clean-contaminated head and neck oncologic surgery. (Arch Otolaryngol Head Neck Surg. 1992;118:1159-1163)
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U2 - 10.1001/archotol.1992.01880110027007
DO - 10.1001/archotol.1992.01880110027007
M3 - Article
C2 - 1418893
AN - SCOPUS:0026460065
SN - 0886-4470
VL - 118
SP - 1159
EP - 1163
JO - Archives of Otolaryngology--Head and Neck Surgery
JF - Archives of Otolaryngology--Head and Neck Surgery
IS - 11
ER -