An AAA+ ATPase Clamshell Targets Transposition

Chi Lin Tsai; Gareth J. Williams; J. Jefferson P. Perry; John A. Tainer

doi:10.1016/j.cell.2015.07.050

An AAA+ ATPase Clamshell Targets Transposition

Chi Lin Tsai, Gareth J. Williams, J. Jefferson P. Perry, John A. Tainer

Molecular & Cellular Oncology

Research output: Contribution to journal › Short survey › peer-review

1 Scopus citations

Abstract

DNA transposition plays key roles in genome diversity, pathogenesis, and evolution. Yet, structural and mechanistic information on transposition targeting and regulation is limited. Arias-Palomo and Berger now define the decameric organization of the AAA+ ATPase IstB, unveiling key insights into its targeting and regulation of IstA transposase activity.

Original language	English (US)
Article number	8365
Pages (from-to)	701-703
Number of pages	3
Journal	Cell
Volume	162
Issue number	4
DOIs	https://doi.org/10.1016/j.cell.2015.07.050
State	Published - Aug 17 2015

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2015.07.050

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title = "An AAA+ ATPase Clamshell Targets Transposition",

abstract = "DNA transposition plays key roles in genome diversity, pathogenesis, and evolution. Yet, structural and mechanistic information on transposition targeting and regulation is limited. Arias-Palomo and Berger now define the decameric organization of the AAA+ ATPase IstB, unveiling key insights into its targeting and regulation of IstA transposase activity.",

author = "Tsai, {Chi Lin} and Williams, {Gareth J.} and Perry, {J. Jefferson P.} and Tainer, {John A.}",

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year = "2015",

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AU - Tsai, Chi Lin

AU - Williams, Gareth J.

AU - Perry, J. Jefferson P.

AU - Tainer, John A.

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Y1 - 2015/8/17

N2 - DNA transposition plays key roles in genome diversity, pathogenesis, and evolution. Yet, structural and mechanistic information on transposition targeting and regulation is limited. Arias-Palomo and Berger now define the decameric organization of the AAA+ ATPase IstB, unveiling key insights into its targeting and regulation of IstA transposase activity.

AB - DNA transposition plays key roles in genome diversity, pathogenesis, and evolution. Yet, structural and mechanistic information on transposition targeting and regulation is limited. Arias-Palomo and Berger now define the decameric organization of the AAA+ ATPase IstB, unveiling key insights into its targeting and regulation of IstA transposase activity.

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An AAA+ ATPase Clamshell Targets Transposition

Abstract

ASJC Scopus subject areas

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