An allelotype of papillary thyroid cancer

Joseph A. Califano, Michael M. Johns, William H. Westra, Miriam N. Lango, David Eisele, Motoyasu Saji, Martha A. Zeiger, Robert Udelsman, Wayne M. Koch, David Sidransky

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Abstract

Although papillary carcinoma accounts for approximately 70% of all thyroid cancers, preliminary studies of allelic loss have thus far not identified any areas of chromosomal deletion. We evaluated 30 papillary thyroid carcinomas for chromosomal loss/allelic imbalance by testing at least 2 microsatellite markers from every autosomal arm. Fifteen of the 30 tumors tested exhibited loss of heterozygosity/allelic imbalance (LOH/AI) at one or more loci. Chromosomal arms with frequent LOH/AI included 4q, 5p, 7p and 11p. An average of 1.1 chromosomal arms displayed LOH/AI in each individual tumor. Therefore, 4q, 5p, 7p and, to a lesser extent, 11p display significant LOH/AI in papillary thyroid cancer, which indicates the presence of putative tumor-suppressor gene loci at these chromosomal arms.

Original languageEnglish (US)
Pages (from-to)442-444
Number of pages3
JournalInternational Journal of Cancer
Volume69
Issue number6
DOIs
StatePublished - Dec 1 1996

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Califano, J. A., Johns, M. M., Westra, W. H., Lango, M. N., Eisele, D., Saji, M., Zeiger, M. A., Udelsman, R., Koch, W. M., & Sidransky, D. (1996). An allelotype of papillary thyroid cancer. International Journal of Cancer, 69(6), 442-444. https://doi.org/10.1002/(SICI)1097-0215(19961220)69:6<442::AID-IJC3>3.0.CO;2-4