An analysis of the presence of fc receptors on bone marrow lymphoblasts in acute lymphoblastic leukemia a pediatric oncology group study

G. Bennett Humphrey; Rebecca Blackstock; John M. Falletta; Richard S. Metzgar; Ellen R. Richie; D. Jeanette Pullen; James M. Boyett; Jonathan J. Shuster; Mary Ann Roper; Edward Clifford Russell; Donald H. Mahoney; Abdel H. Ragab

doi:10.1002/1097-0142(19851015)56:8<1995::AID-CNCR2820560818>3.0.CO;2-2

An analysis of the presence of fc receptors on bone marrow lymphoblasts in acute lymphoblastic leukemia a pediatric oncology group study

G. Bennett Humphrey, Rebecca Blackstock, John M. Falletta, Richard S. Metzgar, Ellen R. Richie, D. Jeanette Pullen, James M. Boyett, Jonathan J. Shuster, Mary Ann Roper, Edward Clifford Russell, Donald H. Mahoney, Abdel H. Ragab

Epigenetics & Molecular Carcinogenesis

Research output: Contribution to journal › Article › peer-review

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Abstract

The presence or absence of the Fc receptor (FcR) on bone marrow lymphoblasts was evaluated in 279 cases of acute lymphoblastic leukemia (ALL) by member institutions of the Pediatric Oncology Group (POG). The case material was classified as follows: 19 cases of positive (⩾20%+), 24 additional cases as intermediate (⩾10% but <20%), and the remaining 236 cases as negative (<10%). Intermediate and positive cases were relatively equally distributed between null cell leukemia and pre‐B‐cell leukemia, and there were one intermediate and two positive T‐cell cases. One of two cases of B‐cell leukemia was also positive. There were no distinguishing clinical or laboratory characteristics which distinguished the FcR⁺ cases, nor was the FcR of prognostic significance within ALL as a group or within immunologically defined phenotypes. Cancer 56: 1995‐2000, 1985.

Original language	English (US)
Pages (from-to)	1995-2000
Number of pages	6
Journal	Cancer
Volume	56
Issue number	8
DOIs	https://doi.org/10.1002/1097-0142(19851015)56:8<1995::AID-CNCR2820560818>3.0.CO;2-2
State	Published - Oct 15 1985

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1002/1097-0142(19851015)56:8<1995::AID-CNCR2820560818>3.0.CO;2-2

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Humphrey, G. B., Blackstock, R., Falletta, J. M., Metzgar, R. S., Richie, E. R., Pullen, D. J., Boyett, J. M., Shuster, J. J., Roper, M. A., Russell, E. C., Mahoney, D. H., & Ragab, A. H. (1985). An analysis of the presence of fc receptors on bone marrow lymphoblasts in acute lymphoblastic leukemia a pediatric oncology group study. Cancer, 56(8), 1995-2000. https://doi.org/10.1002/1097-0142(19851015)56:8<1995::AID-CNCR2820560818>3.0.CO;2-2

Humphrey, GB, Blackstock, R, Falletta, JM, Metzgar, RS, Richie, ER, Pullen, DJ, Boyett, JM, Shuster, JJ, Roper, MA, Russell, EC, Mahoney, DH & Ragab, AH 1985, 'An analysis of the presence of fc receptors on bone marrow lymphoblasts in acute lymphoblastic leukemia a pediatric oncology group study', Cancer, vol. 56, no. 8, pp. 1995-2000. https://doi.org/10.1002/1097-0142(19851015)56:8<1995::AID-CNCR2820560818>3.0.CO;2-2

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abstract = "The presence or absence of the Fc receptor (FcR) on bone marrow lymphoblasts was evaluated in 279 cases of acute lymphoblastic leukemia (ALL) by member institutions of the Pediatric Oncology Group (POG). The case material was classified as follows: 19 cases of positive (⩾20%+), 24 additional cases as intermediate (⩾10% but <20%), and the remaining 236 cases as negative (<10%). Intermediate and positive cases were relatively equally distributed between null cell leukemia and pre‐B‐cell leukemia, and there were one intermediate and two positive T‐cell cases. One of two cases of B‐cell leukemia was also positive. There were no distinguishing clinical or laboratory characteristics which distinguished the FcR+ cases, nor was the FcR of prognostic significance within ALL as a group or within immunologically defined phenotypes. Cancer 56: 1995‐2000, 1985.",

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AU - Pullen, D. Jeanette

AU - Boyett, James M.

AU - Shuster, Jonathan J.

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AU - Russell, Edward Clifford

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AB - The presence or absence of the Fc receptor (FcR) on bone marrow lymphoblasts was evaluated in 279 cases of acute lymphoblastic leukemia (ALL) by member institutions of the Pediatric Oncology Group (POG). The case material was classified as follows: 19 cases of positive (⩾20%+), 24 additional cases as intermediate (⩾10% but <20%), and the remaining 236 cases as negative (<10%). Intermediate and positive cases were relatively equally distributed between null cell leukemia and pre‐B‐cell leukemia, and there were one intermediate and two positive T‐cell cases. One of two cases of B‐cell leukemia was also positive. There were no distinguishing clinical or laboratory characteristics which distinguished the FcR+ cases, nor was the FcR of prognostic significance within ALL as a group or within immunologically defined phenotypes. Cancer 56: 1995‐2000, 1985.

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An analysis of the presence of fc receptors on bone marrow lymphoblasts in acute lymphoblastic leukemia a pediatric oncology group study

Abstract

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