An evolving function of DNA-containing exosomes in chemotherapy-induced immune response

Paul Kurywchak; Raghu Kalluri

doi:10.1038/cr.2017.74

An evolving function of DNA-containing exosomes in chemotherapy-induced immune response

Paul Kurywchak, Raghu Kalluri

Cancer Biology

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Chemotherapy is a predominant strategy to treat cancer and is often associated with toxicities like severe diarrhea that puts patients at additional risk and can hinder treatment strategies. Lian et al. recently explored the immune-mediated mechanisms of Irinotecan-induced diarrhea in colorectal cancer and found that double-stranded DNA in small vesicles can launch inflammation pathways in immune cells through the cytosolic DNA sensor AIM2.

Original language	English (US)
Pages (from-to)	722-723
Number of pages	2
Journal	Cell research
Volume	27
Issue number	6
DOIs	https://doi.org/10.1038/cr.2017.74
State	Published - Jun 1 2017

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1038/cr.2017.74

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abstract = "Chemotherapy is a predominant strategy to treat cancer and is often associated with toxicities like severe diarrhea that puts patients at additional risk and can hinder treatment strategies. Lian et al. recently explored the immune-mediated mechanisms of Irinotecan-induced diarrhea in colorectal cancer and found that double-stranded DNA in small vesicles can launch inflammation pathways in immune cells through the cytosolic DNA sensor AIM2.",

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An evolving function of DNA-containing exosomes in chemotherapy-induced immune response

Abstract

ASJC Scopus subject areas

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