An examination of silver as a radiographic contrast agent in dual-energy breast x-ray imaging

Roshan Karunamuni; Ajlan Al Zaki; Anatoliy V. Popov; E. James Delikatny; Sara Gavenonis; Andrew Tsourkas; Andrew D.A. Maidment

doi:10.1007/978-3-642-31271-7_54

An examination of silver as a radiographic contrast agent in dual-energy breast x-ray imaging

Roshan Karunamuni, Ajlan Al Zaki, Anatoliy V. Popov, E. James Delikatny, Sara Gavenonis, Andrew Tsourkas, Andrew D.A. Maidment

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

6 Scopus citations

Abstract

Silver nanoaprticles have been investigated as an alternative to iodine in dual-energy breast x-ray imaging. Dual-energy imaging involves acquiring images at two distinct energy windows (low and high). Weighting factors are then applied to create an image where the contrast between background tissues has been suppressed. Silver (Ag) represents an attractive contrast material due to its favorable x-ray attenuation properties (k-edge of 25.5 keV). Theoretical analysis using polychromatic spectra shows that silver can provide similar, if not better, contrast to iodine. Spherical Ag nanoparticles with an average diameter of 4 ±2 nm were synthesized using the Brust method in water. The particles were surface stabilized with polyethylene glycol and showed little cellular toxicity in T6-17 fibroblast cells. These results have encouraged further investigation into validation and testing in living system models. Silver nanoparticles represent an exciting avenue for the development of a novel dual-energy, x-ray breast imaging agent.

Original language	English (US)
Title of host publication	Breast Imaging - 11th International Workshop, IWDM 2012, Proceedings
Pages	418-425
Number of pages	8
DOIs	https://doi.org/10.1007/978-3-642-31271-7_54
State	Published - 2012
Externally published	Yes
Event	11th International Workshop on Breast Imaging, IWDM 2012 - Philadelphia, PA, United States Duration: Jul 8 2012 → Jul 11 2012

Publication series

Name	Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume	7361 LNCS
ISSN (Print)	0302-9743
ISSN (Electronic)	1611-3349

Conference

Conference	11th International Workshop on Breast Imaging, IWDM 2012
Country/Territory	United States
City	Philadelphia, PA
Period	7/8/12 → 7/11/12

ASJC Scopus subject areas

Theoretical Computer Science
General Computer Science

Access to Document

10.1007/978-3-642-31271-7_54

Cite this

Karunamuni, R., Zaki, A. A., Popov, A. V., James Delikatny, E., Gavenonis, S., Tsourkas, A., & Maidment, A. D. A. (2012). An examination of silver as a radiographic contrast agent in dual-energy breast x-ray imaging. In Breast Imaging - 11th International Workshop, IWDM 2012, Proceedings (pp. 418-425). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 7361 LNCS). https://doi.org/10.1007/978-3-642-31271-7_54

An examination of silver as a radiographic contrast agent in dual-energy breast x-ray imaging. / Karunamuni, Roshan; Zaki, Ajlan Al; Popov, Anatoliy V. et al.
Breast Imaging - 11th International Workshop, IWDM 2012, Proceedings. 2012. p. 418-425 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 7361 LNCS).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Karunamuni, R, Zaki, AA, Popov, AV, James Delikatny, E, Gavenonis, S, Tsourkas, A & Maidment, ADA 2012, An examination of silver as a radiographic contrast agent in dual-energy breast x-ray imaging. in Breast Imaging - 11th International Workshop, IWDM 2012, Proceedings. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 7361 LNCS, pp. 418-425, 11th International Workshop on Breast Imaging, IWDM 2012, Philadelphia, PA, United States, 7/8/12. https://doi.org/10.1007/978-3-642-31271-7_54

Karunamuni R, Zaki AA, Popov AV, James Delikatny E, Gavenonis S, Tsourkas A et al. An examination of silver as a radiographic contrast agent in dual-energy breast x-ray imaging. In Breast Imaging - 11th International Workshop, IWDM 2012, Proceedings. 2012. p. 418-425. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)). doi: 10.1007/978-3-642-31271-7_54

Karunamuni, Roshan ; Zaki, Ajlan Al ; Popov, Anatoliy V. et al. / An examination of silver as a radiographic contrast agent in dual-energy breast x-ray imaging. Breast Imaging - 11th International Workshop, IWDM 2012, Proceedings. 2012. pp. 418-425 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)).

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abstract = "Silver nanoaprticles have been investigated as an alternative to iodine in dual-energy breast x-ray imaging. Dual-energy imaging involves acquiring images at two distinct energy windows (low and high). Weighting factors are then applied to create an image where the contrast between background tissues has been suppressed. Silver (Ag) represents an attractive contrast material due to its favorable x-ray attenuation properties (k-edge of 25.5 keV). Theoretical analysis using polychromatic spectra shows that silver can provide similar, if not better, contrast to iodine. Spherical Ag nanoparticles with an average diameter of 4 ±2 nm were synthesized using the Brust method in water. The particles were surface stabilized with polyethylene glycol and showed little cellular toxicity in T6-17 fibroblast cells. These results have encouraged further investigation into validation and testing in living system models. Silver nanoparticles represent an exciting avenue for the development of a novel dual-energy, x-ray breast imaging agent.",

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AU - Gavenonis, Sara

AU - Tsourkas, Andrew

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AB - Silver nanoaprticles have been investigated as an alternative to iodine in dual-energy breast x-ray imaging. Dual-energy imaging involves acquiring images at two distinct energy windows (low and high). Weighting factors are then applied to create an image where the contrast between background tissues has been suppressed. Silver (Ag) represents an attractive contrast material due to its favorable x-ray attenuation properties (k-edge of 25.5 keV). Theoretical analysis using polychromatic spectra shows that silver can provide similar, if not better, contrast to iodine. Spherical Ag nanoparticles with an average diameter of 4 ±2 nm were synthesized using the Brust method in water. The particles were surface stabilized with polyethylene glycol and showed little cellular toxicity in T6-17 fibroblast cells. These results have encouraged further investigation into validation and testing in living system models. Silver nanoparticles represent an exciting avenue for the development of a novel dual-energy, x-ray breast imaging agent.

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An examination of silver as a radiographic contrast agent in dual-energy breast x-ray imaging

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