An initial analysis of preoperative serum CA 125 levels in patients with early stage ovarian carcinoma

Vincent R. Zurawski; Robert C. Knapp; Nina Einhorn; Peter Kenemans; Rodrigue Mortel; Kazuo Ohmi; Robert C. Bast; Roy E. Ritts; George Malkasian

doi:10.1016/0090-8258(88)90039-X

An initial analysis of preoperative serum CA 125 levels in patients with early stage ovarian carcinoma

Vincent R. Zurawski, Robert C. Knapp, Nina Einhorn, Peter Kenemans, Rodrigue Mortel, Kazuo Ohmi, Robert C. Bast, Roy E. Ritts, George Malkasian

Research output: Contribution to journal › Article › peer-review

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Abstract

Preoperative serum CA 125 levels were determined for 36 patients with Stage I and II ovarian carcinoma. Levels ranged from 9 to 1962 U/ml with a mean of 216 U/ml. In Stage I patients, CA 125 levels averaged 133 U/ml and in Stage II patients 382 U/ml. Nine of 24 Stage I (38%) and 9 of 12 Stage II patients (75%) had CA 125 levels in excess of 65 U/ml in a population somewhat overrepresented in mucinous tumors. Patients with non-mucinous neoplasms had CA 125 elevations more often-in 75% of the cases-than those with mucinous tumors. A larger study will be required to more precisely estimate the fraction of early stage patients with elevated preoperative serum CA 125 levels; however, this investigation demonstrates an assay sensitivity minimally adequate to initiate a pilot evaluation of serum CA 125 levels in a population at risk for ovarian carcinoma.

Original language	English (US)
Pages (from-to)	7-14
Number of pages	8
Journal	Gynecologic oncology
Volume	30
Issue number	1
DOIs	https://doi.org/10.1016/0090-8258(88)90039-X
State	Published - May 1988
Externally published	Yes

ASJC Scopus subject areas

Oncology
Obstetrics and Gynecology

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@article{63dad80eb28c4175857b12fc07411c27,

title = "An initial analysis of preoperative serum CA 125 levels in patients with early stage ovarian carcinoma",

abstract = "Preoperative serum CA 125 levels were determined for 36 patients with Stage I and II ovarian carcinoma. Levels ranged from 9 to 1962 U/ml with a mean of 216 U/ml. In Stage I patients, CA 125 levels averaged 133 U/ml and in Stage II patients 382 U/ml. Nine of 24 Stage I (38%) and 9 of 12 Stage II patients (75%) had CA 125 levels in excess of 65 U/ml in a population somewhat overrepresented in mucinous tumors. Patients with non-mucinous neoplasms had CA 125 elevations more often-in 75% of the cases-than those with mucinous tumors. A larger study will be required to more precisely estimate the fraction of early stage patients with elevated preoperative serum CA 125 levels; however, this investigation demonstrates an assay sensitivity minimally adequate to initiate a pilot evaluation of serum CA 125 levels in a population at risk for ovarian carcinoma.",

author = "Zurawski, {Vincent R.} and Knapp, {Robert C.} and Nina Einhorn and Peter Kenemans and Rodrigue Mortel and Kazuo Ohmi and Bast, {Robert C.} and Ritts, {Roy E.} and George Malkasian",

note = "Funding Information: The authors are indebted to Ms. Susan Broderick and Mr. David Martin for their assistancei n organizinga nd analyzingt his data and to Ms. Damella Resetarf or her help in preparingt he manuscript. This work was supported in part by grants from the USPHS, NIH No. 1 R43 CA 20945-01( to V.R.Z., Jr.) and from the Dutch Prevention Fund, Praev. Funds 28-1248( to P.K.).",

year = "1988",

month = may,

doi = "10.1016/0090-8258(88)90039-X",

language = "English (US)",

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pages = "7--14",

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AU - Zurawski, Vincent R.

AU - Knapp, Robert C.

AU - Einhorn, Nina

AU - Kenemans, Peter

AU - Mortel, Rodrigue

AU - Ohmi, Kazuo

AU - Bast, Robert C.

AU - Ritts, Roy E.

AU - Malkasian, George

N1 - Funding Information: The authors are indebted to Ms. Susan Broderick and Mr. David Martin for their assistancei n organizinga nd analyzingt his data and to Ms. Damella Resetarf or her help in preparingt he manuscript. This work was supported in part by grants from the USPHS, NIH No. 1 R43 CA 20945-01( to V.R.Z., Jr.) and from the Dutch Prevention Fund, Praev. Funds 28-1248( to P.K.).

PY - 1988/5

Y1 - 1988/5

N2 - Preoperative serum CA 125 levels were determined for 36 patients with Stage I and II ovarian carcinoma. Levels ranged from 9 to 1962 U/ml with a mean of 216 U/ml. In Stage I patients, CA 125 levels averaged 133 U/ml and in Stage II patients 382 U/ml. Nine of 24 Stage I (38%) and 9 of 12 Stage II patients (75%) had CA 125 levels in excess of 65 U/ml in a population somewhat overrepresented in mucinous tumors. Patients with non-mucinous neoplasms had CA 125 elevations more often-in 75% of the cases-than those with mucinous tumors. A larger study will be required to more precisely estimate the fraction of early stage patients with elevated preoperative serum CA 125 levels; however, this investigation demonstrates an assay sensitivity minimally adequate to initiate a pilot evaluation of serum CA 125 levels in a population at risk for ovarian carcinoma.

AB - Preoperative serum CA 125 levels were determined for 36 patients with Stage I and II ovarian carcinoma. Levels ranged from 9 to 1962 U/ml with a mean of 216 U/ml. In Stage I patients, CA 125 levels averaged 133 U/ml and in Stage II patients 382 U/ml. Nine of 24 Stage I (38%) and 9 of 12 Stage II patients (75%) had CA 125 levels in excess of 65 U/ml in a population somewhat overrepresented in mucinous tumors. Patients with non-mucinous neoplasms had CA 125 elevations more often-in 75% of the cases-than those with mucinous tumors. A larger study will be required to more precisely estimate the fraction of early stage patients with elevated preoperative serum CA 125 levels; however, this investigation demonstrates an assay sensitivity minimally adequate to initiate a pilot evaluation of serum CA 125 levels in a population at risk for ovarian carcinoma.

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An initial analysis of preoperative serum CA 125 levels in patients with early stage ovarian carcinoma

Abstract

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