TY - JOUR
T1 - An investigation of risk factors for renal cell carcinoma by histologic subtype in two case-control studies
AU - Purdue, Mark P.
AU - Moore, Lee E.
AU - Merino, Maria J.
AU - Boffetta, Paolo
AU - Colt, Joanne S.
AU - Schwartz, Kendra L.
AU - Bencko, Vladimir
AU - Davis, Faith G.
AU - Graubard, Barry I.
AU - Janout, Vladimir
AU - Ruterbusch, Julie J.
AU - Beebe-Dimmer, Jennifer
AU - Cote, Michele L.
AU - Shuch, Brian
AU - Mates, Dana
AU - Hofmann, Jonathan N.
AU - Foretova, Lenka
AU - Rothman, Nathaniel
AU - Szeszenia-Dabrowska, Neonilia
AU - Matveev, Vsevolod
AU - Wacholder, Sholom
AU - Zaridze, David
AU - Linehan, W. Marston
AU - Brennan, Paul
AU - Chow, Wong Ho
PY - 2013/6/1
Y1 - 2013/6/1
N2 - To investigate whether renal cell carcinoma (RCC) histologic subtypes possess different etiologies, we conducted analyses of established RCC risk factors by subtype (clear cell, papillary and chromophobe) in two case-control studies conducted in the United States (1,217 cases, 1,235 controls) and Europe (1,097 cases, 1,476 controls). Histology was ascertained for 706 U.S. cases (58% of total) and 917 European cases (84%) through a central slide review conducted by a single pathologist. For the remaining cases, histology was abstracted from the original diagnostic pathology report. Case-only analyses were performed to compute odds ratios (ORs) and 95% confidence intervals (CI) summarizing subtype differences by age, sex and race. Case-control analyses were performed to compute subtype-specific ORs for other risk factors using polytomous regression. In case-only analyses, papillary cases (N = 237) were older (OR = 1.2, 95% CI = 1.1-1.4 per 10-year increase), less likely to be female (OR = 0.5, 95% CI = 0.4-0.8) and more likely to be black (OR = 2.6, 95% CI = 1.8-3.9) as compared to clear cell cases (N = 1,524). In case-control analyses, BMI was associated with clear cell (OR = 1.2, 95% CI = 1.1-1.3 per 5 kg/m2 increase) and chromophobe RCC (N = 80; OR = 1.2, 95% CI = 1.1-1.4), but not papillary RCC (OR = 1.1, 95% CI = 1.0-1.2; test versus clear cell, p = 0.006). No subtype differences were observed for associations with smoking, hypertension or family history of kidney cancer. Our findings support the existence of distinct age, sex and racial distributions for RCC subtypes, and suggest that the obesity-RCC association differs by histology.
AB - To investigate whether renal cell carcinoma (RCC) histologic subtypes possess different etiologies, we conducted analyses of established RCC risk factors by subtype (clear cell, papillary and chromophobe) in two case-control studies conducted in the United States (1,217 cases, 1,235 controls) and Europe (1,097 cases, 1,476 controls). Histology was ascertained for 706 U.S. cases (58% of total) and 917 European cases (84%) through a central slide review conducted by a single pathologist. For the remaining cases, histology was abstracted from the original diagnostic pathology report. Case-only analyses were performed to compute odds ratios (ORs) and 95% confidence intervals (CI) summarizing subtype differences by age, sex and race. Case-control analyses were performed to compute subtype-specific ORs for other risk factors using polytomous regression. In case-only analyses, papillary cases (N = 237) were older (OR = 1.2, 95% CI = 1.1-1.4 per 10-year increase), less likely to be female (OR = 0.5, 95% CI = 0.4-0.8) and more likely to be black (OR = 2.6, 95% CI = 1.8-3.9) as compared to clear cell cases (N = 1,524). In case-control analyses, BMI was associated with clear cell (OR = 1.2, 95% CI = 1.1-1.3 per 5 kg/m2 increase) and chromophobe RCC (N = 80; OR = 1.2, 95% CI = 1.1-1.4), but not papillary RCC (OR = 1.1, 95% CI = 1.0-1.2; test versus clear cell, p = 0.006). No subtype differences were observed for associations with smoking, hypertension or family history of kidney cancer. Our findings support the existence of distinct age, sex and racial distributions for RCC subtypes, and suggest that the obesity-RCC association differs by histology.
KW - body mass index
KW - case-control studies
KW - histology
KW - renal cell carcinoma
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UR - http://www.scopus.com/inward/citedby.url?scp=84875588771&partnerID=8YFLogxK
U2 - 10.1002/ijc.27934
DO - 10.1002/ijc.27934
M3 - Article
C2 - 23150424
AN - SCOPUS:84875588771
SN - 0020-7136
VL - 132
SP - 2640
EP - 2647
JO - International journal of cancer
JF - International journal of cancer
IS - 11
ER -