TY - JOUR
T1 - An Overview of the Immune Modulatory Properties of Long Non-Coding RNAs and Their Potential Use as Therapeutic Targets in Cancer
AU - Martinez-Castillo, Moises
AU - M. Elsayed, Abdelrahman
AU - López-Berestein, Gabriel
AU - Amero, Paola
AU - Rodríguez-Aguayo, Cristian
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/12
Y1 - 2023/12
N2 - Long non-coding RNAs (lncRNAs) play pivotal roles in regulating immune responses, immune cell differentiation, activation, and inflammatory processes. In cancer, they are gaining prominence as potential therapeutic targets due to their ability to regulate immune checkpoint molecules and immune-related factors, suggesting avenues for bolstering anti-tumor immune responses. Here, we explore the mechanistic insights into lncRNA-mediated immune modulation, highlighting their impact on immunity. Additionally, we discuss their potential to enhance cancer immunotherapy, augmenting the effectiveness of immune checkpoint inhibitors and adoptive T cell therapies. LncRNAs as therapeutic targets hold the promise of revolutionizing cancer treatments, inspiring further research in this field with substantial clinical implications.
AB - Long non-coding RNAs (lncRNAs) play pivotal roles in regulating immune responses, immune cell differentiation, activation, and inflammatory processes. In cancer, they are gaining prominence as potential therapeutic targets due to their ability to regulate immune checkpoint molecules and immune-related factors, suggesting avenues for bolstering anti-tumor immune responses. Here, we explore the mechanistic insights into lncRNA-mediated immune modulation, highlighting their impact on immunity. Additionally, we discuss their potential to enhance cancer immunotherapy, augmenting the effectiveness of immune checkpoint inhibitors and adoptive T cell therapies. LncRNAs as therapeutic targets hold the promise of revolutionizing cancer treatments, inspiring further research in this field with substantial clinical implications.
KW - biomarkers
KW - cancer
KW - immune response
KW - immunotherapy
KW - lncRNA
KW - ncRNA
UR - http://www.scopus.com/inward/record.url?scp=85180476878&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85180476878&partnerID=8YFLogxK
U2 - 10.3390/ncrna9060070
DO - 10.3390/ncrna9060070
M3 - Review article
C2 - 37987366
AN - SCOPUS:85180476878
SN - 2311-553X
VL - 9
JO - Non-coding RNA
JF - Non-coding RNA
IS - 6
M1 - 70
ER -