An update of a phase II study of paclitaxel in advanced or recurrent squamous cell cancer of the cervix

Andrzej P. Kudelka; Rodger Winn; Creighton L. Edwards; G. Downey; Harvey Greenberg; S. R. Dakhil; Ralph S. Freedman; Salvatore LoCoco; J. Umbreit; James E. Delmore; Susan Arbuck; Evelyne Loyer; Patsy Gacrama; Rebecca Fueger; John J. Kavanagh

doi:10.1097/00001813-199708000-00002

An update of a phase II study of paclitaxel in advanced or recurrent squamous cell cancer of the cervix

Andrzej P. Kudelka, Rodger Winn, Creighton L. Edwards, G. Downey, Harvey Greenberg, S. R. Dakhil, Ralph S. Freedman, Salvatore LoCoco, J. Umbreit, James E. Delmore, Susan Arbuck, Evelyne Loyer, Patsy Gacrama, Rebecca Fueger, John J. Kavanagh

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Abstract

Thirty-two evaluable patients with squamous cell cancer of the cervix were treated with i.v. paclitaxel 250 mg/m² over 3 h every 21 days. They received standard premedications and granulocyte colony stimulating factor (G-CSF) support (5 μg/kg/day). Median (range) age was 49 (29-81) years and performance status Zubrod was 1 (0-2). One patient had a complete response and seven patients had a partial response (25%, 95% CI 8-38%). The median survival was 7.3 months. Granulocytopenia was brief and non-cumulative. G-CSF was used for a median (range) of 8 (1-15) days per cycle. In conclusion: paclitaxel is active in patients with squamous cell cancer of the cervix and is well tolerated in this dose schedule with G-CSF support.

Original language	English (US)
Pages (from-to)	657-661
Number of pages	5
Journal	Anti-cancer drugs
Volume	8
Issue number	7
DOIs	https://doi.org/10.1097/00001813-199708000-00002
State	Published - 1997

Keywords

Cervix cancer
Granulocyte colony stimulating factor
Paclitaxel

ASJC Scopus subject areas

Oncology
Pharmacology
Pharmacology (medical)
Cancer Research

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10.1097/00001813-199708000-00002

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Kudelka, A. P., Winn, R., Edwards, C. L., Downey, G., Greenberg, H., Dakhil, S. R., Freedman, R. S., LoCoco, S., Umbreit, J., Delmore, J. E., Arbuck, S., Loyer, E., Gacrama, P., Fueger, R., & Kavanagh, J. J. (1997). An update of a phase II study of paclitaxel in advanced or recurrent squamous cell cancer of the cervix. Anti-cancer drugs, 8(7), 657-661. https://doi.org/10.1097/00001813-199708000-00002

Kudelka, AP, Winn, R, Edwards, CL, Downey, G, Greenberg, H, Dakhil, SR, Freedman, RS, LoCoco, S, Umbreit, J, Delmore, JE, Arbuck, S, Loyer, E, Gacrama, P, Fueger, R & Kavanagh, JJ 1997, 'An update of a phase II study of paclitaxel in advanced or recurrent squamous cell cancer of the cervix', Anti-cancer drugs, vol. 8, no. 7, pp. 657-661. https://doi.org/10.1097/00001813-199708000-00002

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An update of a phase II study of paclitaxel in advanced or recurrent squamous cell cancer of the cervix

Abstract

Keywords

ASJC Scopus subject areas

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