Anal Carcinoma, Version 2.2023

Al B. Benson; Alan P. Venook; Mahmoud M. Al-Hawary; Nilofer Azad; Yi Jen Chen; Kristen K. Ciombor; Stacey Cohen; Harry S. Cooper; Dustin Deming; Ignacio Garrido-Laguna; Jean L. Grem; J. Randolph Hecht; Sarah Hoffe; Joleen Hubbard; Steven Hunt; Hisham Hussan; William Jeck; Kimberly L. Johung; Nora Joseph; Natalie Kirilcuk; Smitha Krishnamurthi; Jennifer Maratt; Wells A. Messersmith; Jeffrey Meyerhardt; Eric D. Miller; Mary F. Mulcahy; Steven Nurkin; Michael J. Overman; Aparna Parikh; Hitendra Patel; Katrina Pedersen; Leonard Saltz; Charles Schneider; David Shibata; John M. Skibber; Constantinos T. Sofocleous; Eden Stotsky-Himelfarb; Anna Tavakkoli; Christopher G. Willett; Grant Williams; Frankie Algieri; Lisa Gurski; P. A.C. Katie Stehman

doi:10.6004/jnccn.2023.0030

Anal Carcinoma, Version 2.2023

Al B. Benson, Alan P. Venook, Mahmoud M. Al-Hawary, Nilofer Azad, Yi Jen Chen, Kristen K. Ciombor, Stacey Cohen, Harry S. Cooper, Dustin Deming, Ignacio Garrido-Laguna, Jean L. Grem, J. Randolph Hecht, Sarah Hoffe, Joleen Hubbard, Steven Hunt, Hisham Hussan, William Jeck, Kimberly L. Johung, Nora Joseph, Natalie KirilcukSmitha Krishnamurthi, Jennifer Maratt, Wells A. Messersmith, Jeffrey Meyerhardt, Eric D. Miller, Mary F. Mulcahy, Steven Nurkin, Michael J. Overman, Aparna Parikh, Hitendra Patel, Katrina Pedersen, Leonard Saltz, Charles Schneider, David Shibata, John M. Skibber, Constantinos T. Sofocleous, Eden Stotsky-Himelfarb, Anna Tavakkoli, Christopher G. Willett, Grant Williams, Frankie Algieri, Lisa Gurski, P. A.C. Katie Stehman

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

This discussion summarizes the NCCN Clinical Practice Guidelines for managing squamous cell anal carcinoma, which represents the most common histologic form of the disease. A multidisciplinary approach including physicians from gastroenterology, medical oncology, surgical oncology, radiation oncology, and radiology is necessary. Primary treatment of perianal cancer and anal canal cancer are similar and include chemoradiation in most cases. Follow-up clinical evaluations are recommended for all patients with anal carcinoma because additional curative-intent treatment is possible. Biopsy-proven evidence of locally recurrent or persistent disease after primary treatment may require surgical treatment. Systemic therapy is generally recommended for extrapelvic metastatic disease. Recent updates to the NCCN Guidelines for Anal Carcinoma include staging classification updates based on the 9th edition of the AJCC Staging System and updates to the systemic therapy recommendations based on new data that better define optimal treatment of patients with metastatic anal carcinoma.

Original language	English (US)
Pages (from-to)	653-677
Number of pages	25
Journal	JNCCN Journal of the National Comprehensive Cancer Network
Volume	21
Issue number	6
DOIs	https://doi.org/10.6004/jnccn.2023.0030
State	Published - Jun 2023

ASJC Scopus subject areas

Oncology

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10.6004/jnccn.2023.0030

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Benson, A. B., Venook, A. P., Al-Hawary, M. M., Azad, N., Chen, Y. J., Ciombor, K. K., Cohen, S., Cooper, H. S., Deming, D., Garrido-Laguna, I., Grem, J. L., Randolph Hecht, J., Hoffe, S., Hubbard, J., Hunt, S., Hussan, H., Jeck, W., Johung, K. L., Joseph, N., ... Katie Stehman, P. A. C. (2023). Anal Carcinoma, Version 2.2023. JNCCN Journal of the National Comprehensive Cancer Network, 21(6), 653-677. https://doi.org/10.6004/jnccn.2023.0030

Benson, AB, Venook, AP, Al-Hawary, MM, Azad, N, Chen, YJ, Ciombor, KK, Cohen, S, Cooper, HS, Deming, D, Garrido-Laguna, I, Grem, JL, Randolph Hecht, J, Hoffe, S, Hubbard, J, Hunt, S, Hussan, H, Jeck, W, Johung, KL, Joseph, N, Kirilcuk, N, Krishnamurthi, S, Maratt, J, Messersmith, WA, Meyerhardt, J, Miller, ED, Mulcahy, MF, Nurkin, S, Overman, MJ, Parikh, A, Patel, H, Pedersen, K, Saltz, L, Schneider, C, Shibata, D, Skibber, JM, Sofocleous, CT, Stotsky-Himelfarb, E, Tavakkoli, A, Willett, CG, Williams, G, Algieri, F, Gurski, L & Katie Stehman, PAC 2023, 'Anal Carcinoma, Version 2.2023', JNCCN Journal of the National Comprehensive Cancer Network, vol. 21, no. 6, pp. 653-677. https://doi.org/10.6004/jnccn.2023.0030

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title = "Anal Carcinoma, Version 2.2023",

abstract = "This discussion summarizes the NCCN Clinical Practice Guidelines for managing squamous cell anal carcinoma, which represents the most common histologic form of the disease. A multidisciplinary approach including physicians from gastroenterology, medical oncology, surgical oncology, radiation oncology, and radiology is necessary. Primary treatment of perianal cancer and anal canal cancer are similar and include chemoradiation in most cases. Follow-up clinical evaluations are recommended for all patients with anal carcinoma because additional curative-intent treatment is possible. Biopsy-proven evidence of locally recurrent or persistent disease after primary treatment may require surgical treatment. Systemic therapy is generally recommended for extrapelvic metastatic disease. Recent updates to the NCCN Guidelines for Anal Carcinoma include staging classification updates based on the 9th edition of the AJCC Staging System and updates to the systemic therapy recommendations based on new data that better define optimal treatment of patients with metastatic anal carcinoma.",

author = "Benson, {Al B.} and Venook, {Alan P.} and Al-Hawary, {Mahmoud M.} and Nilofer Azad and Chen, {Yi Jen} and Ciombor, {Kristen K.} and Stacey Cohen and Cooper, {Harry S.} and Dustin Deming and Ignacio Garrido-Laguna and Grem, {Jean L.} and {Randolph Hecht}, J. and Sarah Hoffe and Joleen Hubbard and Steven Hunt and Hisham Hussan and William Jeck and Johung, {Kimberly L.} and Nora Joseph and Natalie Kirilcuk and Smitha Krishnamurthi and Jennifer Maratt and Messersmith, {Wells A.} and Jeffrey Meyerhardt and Miller, {Eric D.} and Mulcahy, {Mary F.} and Steven Nurkin and Overman, {Michael J.} and Aparna Parikh and Hitendra Patel and Katrina Pedersen and Leonard Saltz and Charles Schneider and David Shibata and Skibber, {John M.} and Sofocleous, {Constantinos T.} and Eden Stotsky-Himelfarb and Anna Tavakkoli and Willett, {Christopher G.} and Grant Williams and Frankie Algieri and Lisa Gurski and {Katie Stehman}, {P. A.C.}",

year = "2023",

month = jun,

doi = "10.6004/jnccn.2023.0030",

language = "English (US)",

volume = "21",

pages = "653--677",

journal = "JNCCN Journal of the National Comprehensive Cancer Network",

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T1 - Anal Carcinoma, Version 2.2023

AU - Benson, Al B.

AU - Venook, Alan P.

AU - Al-Hawary, Mahmoud M.

AU - Azad, Nilofer

AU - Chen, Yi Jen

AU - Ciombor, Kristen K.

AU - Cohen, Stacey

AU - Cooper, Harry S.

AU - Deming, Dustin

AU - Garrido-Laguna, Ignacio

AU - Grem, Jean L.

AU - Randolph Hecht, J.

AU - Hoffe, Sarah

AU - Hubbard, Joleen

AU - Hunt, Steven

AU - Hussan, Hisham

AU - Jeck, William

AU - Johung, Kimberly L.

AU - Joseph, Nora

AU - Kirilcuk, Natalie

AU - Krishnamurthi, Smitha

AU - Maratt, Jennifer

AU - Messersmith, Wells A.

AU - Meyerhardt, Jeffrey

AU - Miller, Eric D.

AU - Mulcahy, Mary F.

AU - Nurkin, Steven

AU - Overman, Michael J.

AU - Parikh, Aparna

AU - Patel, Hitendra

AU - Pedersen, Katrina

AU - Saltz, Leonard

AU - Schneider, Charles

AU - Shibata, David

AU - Skibber, John M.

AU - Sofocleous, Constantinos T.

AU - Stotsky-Himelfarb, Eden

AU - Tavakkoli, Anna

AU - Willett, Christopher G.

AU - Williams, Grant

AU - Algieri, Frankie

AU - Gurski, Lisa

AU - Katie Stehman, P. A.C.

PY - 2023/6

Y1 - 2023/6

N2 - This discussion summarizes the NCCN Clinical Practice Guidelines for managing squamous cell anal carcinoma, which represents the most common histologic form of the disease. A multidisciplinary approach including physicians from gastroenterology, medical oncology, surgical oncology, radiation oncology, and radiology is necessary. Primary treatment of perianal cancer and anal canal cancer are similar and include chemoradiation in most cases. Follow-up clinical evaluations are recommended for all patients with anal carcinoma because additional curative-intent treatment is possible. Biopsy-proven evidence of locally recurrent or persistent disease after primary treatment may require surgical treatment. Systemic therapy is generally recommended for extrapelvic metastatic disease. Recent updates to the NCCN Guidelines for Anal Carcinoma include staging classification updates based on the 9th edition of the AJCC Staging System and updates to the systemic therapy recommendations based on new data that better define optimal treatment of patients with metastatic anal carcinoma.

AB - This discussion summarizes the NCCN Clinical Practice Guidelines for managing squamous cell anal carcinoma, which represents the most common histologic form of the disease. A multidisciplinary approach including physicians from gastroenterology, medical oncology, surgical oncology, radiation oncology, and radiology is necessary. Primary treatment of perianal cancer and anal canal cancer are similar and include chemoradiation in most cases. Follow-up clinical evaluations are recommended for all patients with anal carcinoma because additional curative-intent treatment is possible. Biopsy-proven evidence of locally recurrent or persistent disease after primary treatment may require surgical treatment. Systemic therapy is generally recommended for extrapelvic metastatic disease. Recent updates to the NCCN Guidelines for Anal Carcinoma include staging classification updates based on the 9th edition of the AJCC Staging System and updates to the systemic therapy recommendations based on new data that better define optimal treatment of patients with metastatic anal carcinoma.

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DO - 10.6004/jnccn.2023.0030

M3 - Article

C2 - 37308125

AN - SCOPUS:85163141944

SN - 1540-1405

VL - 21

SP - 653

EP - 677

JO - JNCCN Journal of the National Comprehensive Cancer Network

JF - JNCCN Journal of the National Comprehensive Cancer Network

IS - 6

ER -

Anal Carcinoma, Version 2.2023

Abstract

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