Analysis of complete responders after initial treatment with chemotherapy in head and neck cancer

M. S. Kies; L. I. Gordon; W. W. Hauck; Y. Krespi; R. H. Ossoff; B. C. Pecaro; C. Yuska; C. H. Lamut; W. N. Brand; S. K. Chang

doi:10.1177/019459988509300213

Analysis of complete responders after initial treatment with chemotherapy in head and neck cancer

M. S. Kies, L. I. Gordon, W. W. Hauck, Y. Krespi, R. H. Ossoff, B. C. Pecaro, C. Yuska, C. H. Lamut, W. N. Brand, S. K. Chang

Thoracic Head & Neck Medical Oncology

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

We treated 60 patients with cisplatin-based combination chemotherapy before definitive surgery and/or radiation. All had squamous cell tumors of the head and neck, stages II to IV, M₀. Twelve patients (20%) achieved a complete remission after chemotherapy. Eight of these patients showed no histologic evidence of residual disease after biopsy or surgery. Definitive local therapy with surgery and/or radiation was carried out on almost all patients regardless of the extent of the response to preceding chemotherapy. Chemotherapy-induced complete responders have had an improved survival rate in comparison with patients achieving a partial response or less. The extent of primary tumor correlates inversely with a complete response to chemotherapy.

Original language	English (US)
Pages (from-to)	199-205
Number of pages	7
Journal	Otolaryngology - Head and Neck Surgery
Volume	93
Issue number	2
DOIs	https://doi.org/10.1177/019459988509300213
State	Published - 1985

ASJC Scopus subject areas

Surgery
Otorhinolaryngology

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title = "Analysis of complete responders after initial treatment with chemotherapy in head and neck cancer",

abstract = "We treated 60 patients with cisplatin-based combination chemotherapy before definitive surgery and/or radiation. All had squamous cell tumors of the head and neck, stages II to IV, M0. Twelve patients (20%) achieved a complete remission after chemotherapy. Eight of these patients showed no histologic evidence of residual disease after biopsy or surgery. Definitive local therapy with surgery and/or radiation was carried out on almost all patients regardless of the extent of the response to preceding chemotherapy. Chemotherapy-induced complete responders have had an improved survival rate in comparison with patients achieving a partial response or less. The extent of primary tumor correlates inversely with a complete response to chemotherapy.",

author = "Kies, {M. S.} and Gordon, {L. I.} and Hauck, {W. W.} and Y. Krespi and Ossoff, {R. H.} and Pecaro, {B. C.} and C. Yuska and Lamut, {C. H.} and Brand, {W. N.} and Chang, {S. K.}",

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T1 - Analysis of complete responders after initial treatment with chemotherapy in head and neck cancer

AU - Kies, M. S.

AU - Gordon, L. I.

AU - Hauck, W. W.

AU - Krespi, Y.

AU - Ossoff, R. H.

AU - Pecaro, B. C.

AU - Yuska, C.

AU - Lamut, C. H.

AU - Brand, W. N.

AU - Chang, S. K.

PY - 1985

Y1 - 1985

N2 - We treated 60 patients with cisplatin-based combination chemotherapy before definitive surgery and/or radiation. All had squamous cell tumors of the head and neck, stages II to IV, M0. Twelve patients (20%) achieved a complete remission after chemotherapy. Eight of these patients showed no histologic evidence of residual disease after biopsy or surgery. Definitive local therapy with surgery and/or radiation was carried out on almost all patients regardless of the extent of the response to preceding chemotherapy. Chemotherapy-induced complete responders have had an improved survival rate in comparison with patients achieving a partial response or less. The extent of primary tumor correlates inversely with a complete response to chemotherapy.

AB - We treated 60 patients with cisplatin-based combination chemotherapy before definitive surgery and/or radiation. All had squamous cell tumors of the head and neck, stages II to IV, M0. Twelve patients (20%) achieved a complete remission after chemotherapy. Eight of these patients showed no histologic evidence of residual disease after biopsy or surgery. Definitive local therapy with surgery and/or radiation was carried out on almost all patients regardless of the extent of the response to preceding chemotherapy. Chemotherapy-induced complete responders have had an improved survival rate in comparison with patients achieving a partial response or less. The extent of primary tumor correlates inversely with a complete response to chemotherapy.

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Analysis of complete responders after initial treatment with chemotherapy in head and neck cancer

Abstract

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