Analysis of differential BRAFV600E mutational status in high aggressive papillary thyroid microcarcinoma

Xiaolong Li, Ming Gao, Yifeng Ji, Yang Yu, Ying Feng, Yigong Li, Yan Zhang, Wenyuan Cheng, wenchuan Zhao

Research output: Contribution to journalArticle

117 Citations (Scopus)

Abstract

Papillary thyroid cancers often occur as microcarcinoma. Some papillary thyroid microcarcinoma (PTMC) have been considered to be high aggressive according to advanced disease stages, extrathyroidal extension, and severe cervical lymph node metastasis. Although several factors are thought to predict the occurrence of aggressiveness from PTMCs, the origin of aggressiveness has been rarely studied. To answer this question, the correlation between BRAF V600E mutation and high aggressive PTMCs was investigated. The clinicopathological characteristic of totally 64 cases of PTMCs was investigated and the BRAFV600E mutational status of them was identified. BRAFV600E mutation was exclusively detected in PTMCs (37.5%). The data provided no correlation between the occurrence of BRAFV600E mutations and clinicopathological parameters, such as sex, age, and tumor-like lesions combination. The prevalence of BRAFV600E mutation of PTMCs with high aggressiveness (advanced disease stages, extrathyroidal extension, and nodal metastasis) was significantly higher (p < 0.05) than that of PTMCs without aggressive behavior. The BRAFV600E mutated PTMCs exhibited signs of higher aggressiveness than PTMCs without the mutation. BRAF V600E mutation may be a marker of high aggressiveness in PTMCs.

Original languageEnglish (US)
Pages (from-to)240-245
Number of pages6
JournalAnnals of surgical oncology
Volume16
Issue number2
DOIs
StatePublished - Feb 1 2009

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Mutation
Neoplasm Metastasis
Papillary Thyroid Microcarcinoma
Lymph Nodes
Neoplasms

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Analysis of differential BRAFV600E mutational status in high aggressive papillary thyroid microcarcinoma. / Li, Xiaolong; Gao, Ming; Ji, Yifeng; Yu, Yang; Feng, Ying; Li, Yigong; Zhang, Yan; Cheng, Wenyuan; Zhao, wenchuan.

In: Annals of surgical oncology, Vol. 16, No. 2, 01.02.2009, p. 240-245.

Research output: Contribution to journalArticle

Li, Xiaolong ; Gao, Ming ; Ji, Yifeng ; Yu, Yang ; Feng, Ying ; Li, Yigong ; Zhang, Yan ; Cheng, Wenyuan ; Zhao, wenchuan. / Analysis of differential BRAFV600E mutational status in high aggressive papillary thyroid microcarcinoma. In: Annals of surgical oncology. 2009 ; Vol. 16, No. 2. pp. 240-245.
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