Analysis of histiocytosis X infiltrates with monoclonal antibodies directed against cells of histiocytic, lymphoid, and myeloid lineage

Euan M. McMillan; G. Bennett Humphrey; Lloyd Stoneking; Lewis C. Strauss; Curt I. Civin; Toru Abo; Charles Balch

doi:10.1016/0090-1229(86)90239-4

Analysis of histiocytosis X infiltrates with monoclonal antibodies directed against cells of histiocytic, lymphoid, and myeloid lineage

Euan M. McMillan, G. Bennett Humphrey, Lloyd Stoneking, Lewis C. Strauss, Curt I. Civin, Toru Abo, Charles Balch

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Surface markers expressed on histiocytosis X (HX) cells were studied using 18 monoclonal antibodies (McAbs) and an in situ indirect immunoperoxidase technique. Specimens of skin (five biopsies from three cases) and lymph node (one case) were studied. Our study confirmed previous findings of an OKT6⁺ HLA DR⁺ Leu 3a⁺ phenotype of HX cells in skin and indicated that lymph node HX cells can also have this phenotype. A mixture of cells expressing T markers/T subset, monocyte/macrophage, and killer/natural killer ( K NK) markers was also present in two cases. However, one case with an aggressive course showed no detectable HNK 1⁺ ( K NK) or Leu 2A (suppressor) cells in the cutaneous infiltrates and no detectable HNK 1⁺ lymphocytes in an affected lymph node. The significance of these findings in relation to prognosis and therapy is discussed.

Original language	English (US)
Pages (from-to)	295-301
Number of pages	7
Journal	Clinical Immunology and Immunopathology
Volume	38
Issue number	3
DOIs	https://doi.org/10.1016/0090-1229(86)90239-4
State	Published - Mar 1986
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Pathology and Forensic Medicine
Immunology

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10.1016/0090-1229(86)90239-4

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title = "Analysis of histiocytosis X infiltrates with monoclonal antibodies directed against cells of histiocytic, lymphoid, and myeloid lineage",

abstract = "Surface markers expressed on histiocytosis X (HX) cells were studied using 18 monoclonal antibodies (McAbs) and an in situ indirect immunoperoxidase technique. Specimens of skin (five biopsies from three cases) and lymph node (one case) were studied. Our study confirmed previous findings of an OKT6+ HLA DR+ Leu 3a+ phenotype of HX cells in skin and indicated that lymph node HX cells can also have this phenotype. A mixture of cells expressing T markers/T subset, monocyte/macrophage, and killer/natural killer ( K NK) markers was also present in two cases. However, one case with an aggressive course showed no detectable HNK 1+ ( K NK) or Leu 2A (suppressor) cells in the cutaneous infiltrates and no detectable HNK 1+ lymphocytes in an affected lymph node. The significance of these findings in relation to prognosis and therapy is discussed.",

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AU - McMillan, Euan M.

AU - Humphrey, G. Bennett

AU - Stoneking, Lloyd

AU - Strauss, Lewis C.

AU - Civin, Curt I.

AU - Abo, Toru

AU - Balch, Charles

PY - 1986/3

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N2 - Surface markers expressed on histiocytosis X (HX) cells were studied using 18 monoclonal antibodies (McAbs) and an in situ indirect immunoperoxidase technique. Specimens of skin (five biopsies from three cases) and lymph node (one case) were studied. Our study confirmed previous findings of an OKT6+ HLA DR+ Leu 3a+ phenotype of HX cells in skin and indicated that lymph node HX cells can also have this phenotype. A mixture of cells expressing T markers/T subset, monocyte/macrophage, and killer/natural killer ( K NK) markers was also present in two cases. However, one case with an aggressive course showed no detectable HNK 1+ ( K NK) or Leu 2A (suppressor) cells in the cutaneous infiltrates and no detectable HNK 1+ lymphocytes in an affected lymph node. The significance of these findings in relation to prognosis and therapy is discussed.

AB - Surface markers expressed on histiocytosis X (HX) cells were studied using 18 monoclonal antibodies (McAbs) and an in situ indirect immunoperoxidase technique. Specimens of skin (five biopsies from three cases) and lymph node (one case) were studied. Our study confirmed previous findings of an OKT6+ HLA DR+ Leu 3a+ phenotype of HX cells in skin and indicated that lymph node HX cells can also have this phenotype. A mixture of cells expressing T markers/T subset, monocyte/macrophage, and killer/natural killer ( K NK) markers was also present in two cases. However, one case with an aggressive course showed no detectable HNK 1+ ( K NK) or Leu 2A (suppressor) cells in the cutaneous infiltrates and no detectable HNK 1+ lymphocytes in an affected lymph node. The significance of these findings in relation to prognosis and therapy is discussed.

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Analysis of histiocytosis X infiltrates with monoclonal antibodies directed against cells of histiocytic, lymphoid, and myeloid lineage

Abstract

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