TY - JOUR
T1 - Analysis of lidocaine and its dealkylated metabolites by high-pressure liquid chromatography
AU - Wisnicki, J. L.
AU - Tong, W. P.
AU - Ludlum, D. B.
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1979/4/16
Y1 - 1979/4/16
N2 - A high-pressure liquid Chromatographic method is presented for determining lidocaine and its dealkylated metabolites, monoethylglycinexylidide and glycinexylidide, in plasma. This method uses 20-μl samples injected directly through a pre-column onto a C18 analytical column. It is fast, sensitive and linear over a concentration range of 1-10 μg/ml. Since the method requires no preliminary treatment of the plasma, it provides a practical means of monitoring lidocaine and its metabolites in therapeutic situations.
AB - A high-pressure liquid Chromatographic method is presented for determining lidocaine and its dealkylated metabolites, monoethylglycinexylidide and glycinexylidide, in plasma. This method uses 20-μl samples injected directly through a pre-column onto a C18 analytical column. It is fast, sensitive and linear over a concentration range of 1-10 μg/ml. Since the method requires no preliminary treatment of the plasma, it provides a practical means of monitoring lidocaine and its metabolites in therapeutic situations.
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U2 - 10.1016/0009-8981(79)90100-1
DO - 10.1016/0009-8981(79)90100-1
M3 - Article
C2 - 445847
AN - SCOPUS:0018746982
SN - 0009-8981
VL - 93
SP - 279
EP - 282
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
IS - 2
ER -