TY - JOUR
T1 - Analysis of prognostic factors in peripheral T-cell lymphoma
T2 - Prognostic value of Serum Albumin and Mediastinal Lymphadenopathy
AU - Chihara, Dai
AU - Oki, Yasuhiro
AU - Ine, Shouji
AU - Yamamoto, Kazuhito
AU - Kato, Harumi
AU - Taji, Hirofumi
AU - Kagami, Yoshitoyo
AU - Yatabe, Yasushi
AU - Nakamura, Shigeo
AU - Morishima, Yasuo
PY - 2009/12
Y1 - 2009/12
N2 - We evaluated multiple patient characteristics for their prognostic significance in patients with peripheral T-cell lymphoma (angioimmunoblastic T-cell lymphoma [AITL; n = 31] and peripheral T-cell lymphoma, not otherwise unspecified [PTCL-NOS; n = 37]). Five-year overall survival (OS) rates in AITL and PTCL-NOS were 49% and 45%, respectively (p = 0.89). Cox proportional hazard model revealed that male sex, hemoglobin <10.0g/dL and performance status (PS) ≥2 were independently associated with shorter OS in AITL. In patients with PTCL-NOS, low albumin, PS≥2, and mediastinal lymphadenopathy were independently associated with worse OS. When analysis in PTCL-NOS was performed incorporating Prognostic Index for PTCLu (PIT), low albumin and mediastinal lymphadenopathy were still both prognostic for OS. Three-year progression free survival (PFS) rates in AITL and PTCL-NOS were 49% and 47%, respectively (p = 0.578). None of the parameters was significantly associated with shorter PFS in AITL. In patients with PTCL-NOS, PS≥2 and mediastinal lymphadenopathy were independently associated with shorter PFS. The result is in keeping with previous large scale studies. Besides, we showed the potential prognostic importance of albumin and mediastinal lymphadenopathy in patients with PTCL-NOS.
AB - We evaluated multiple patient characteristics for their prognostic significance in patients with peripheral T-cell lymphoma (angioimmunoblastic T-cell lymphoma [AITL; n = 31] and peripheral T-cell lymphoma, not otherwise unspecified [PTCL-NOS; n = 37]). Five-year overall survival (OS) rates in AITL and PTCL-NOS were 49% and 45%, respectively (p = 0.89). Cox proportional hazard model revealed that male sex, hemoglobin <10.0g/dL and performance status (PS) ≥2 were independently associated with shorter OS in AITL. In patients with PTCL-NOS, low albumin, PS≥2, and mediastinal lymphadenopathy were independently associated with worse OS. When analysis in PTCL-NOS was performed incorporating Prognostic Index for PTCLu (PIT), low albumin and mediastinal lymphadenopathy were still both prognostic for OS. Three-year progression free survival (PFS) rates in AITL and PTCL-NOS were 49% and 47%, respectively (p = 0.578). None of the parameters was significantly associated with shorter PFS in AITL. In patients with PTCL-NOS, PS≥2 and mediastinal lymphadenopathy were independently associated with shorter PFS. The result is in keeping with previous large scale studies. Besides, we showed the potential prognostic importance of albumin and mediastinal lymphadenopathy in patients with PTCL-NOS.
KW - Angioimmunoblastic lymphoma
KW - Mediastinal lymphadenopathy
KW - Peripheral T-cell lymphoma
KW - Peripheral T-cell lymphoma not otherwise specified
KW - Prognostic factor
KW - Serum albumin
UR - http://www.scopus.com/inward/record.url?scp=72949091680&partnerID=8YFLogxK
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U2 - 10.3109/10428190903318311
DO - 10.3109/10428190903318311
M3 - Article
C2 - 19860627
AN - SCOPUS:72949091680
SN - 1042-8194
VL - 50
SP - 1999
EP - 2004
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 12
ER -