TY - JOUR
T1 - Anaplastic ameloblastic fibrosarcoma arising from recurrent ameloblastic fibroma
T2 - restricted molecular abnormalities of certain genes to the malignant transformation
AU - Williams, Michelle D.
AU - Hanna, Ehab Y.
AU - El-Naggar, Adel K.
PY - 2007/7
Y1 - 2007/7
N2 - A rare case of anaplastic ameloblastic fibrosarcoma (AS) arising in an ameloblastic fibroma (AF) of the maxilla of a 48-year-old patient 10 years after the primary excision is presented. The recurrent tumor retained focal areas of AF but manifested heterogeneous malignant features ranging from low-grade spindle to highly pleomorphic sarcomas. Biomarker analysis showed alterations of the p53 and c-KIT genes restricted to the sarcomatous component. The biological implications of these findings in the future management of these tumors are discussed.
AB - A rare case of anaplastic ameloblastic fibrosarcoma (AS) arising in an ameloblastic fibroma (AF) of the maxilla of a 48-year-old patient 10 years after the primary excision is presented. The recurrent tumor retained focal areas of AF but manifested heterogeneous malignant features ranging from low-grade spindle to highly pleomorphic sarcomas. Biomarker analysis showed alterations of the p53 and c-KIT genes restricted to the sarcomatous component. The biological implications of these findings in the future management of these tumors are discussed.
UR - http://www.scopus.com/inward/record.url?scp=34250164181&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34250164181&partnerID=8YFLogxK
U2 - 10.1016/j.tripleo.2006.07.013
DO - 10.1016/j.tripleo.2006.07.013
M3 - Article
C2 - 17577546
AN - SCOPUS:34250164181
SN - 1079-2104
VL - 104
SP - 72
EP - 75
JO - Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology
JF - Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology
IS - 1
ER -