Abstract
Session 8 of the 2005 Society of Hematopathology/European Association for Haematopathology Workshop was devoted to anaplastic large cell lymphoma (ALCL). Most cases submitted were anaplastic lymphoma kinase (ALK)+ ALCL highlighting unusual clinical settings, histologic variants, and variant translocation partners. Cases submitted as ALK- ALCL emphasized the immunohistochemical overlap with classical Hodgkin lymphoma (eg, CD15+/CD30+). It was also clear that consensus histologic and immunohistochemical criteria for the diagnosis of ALK- ALCL are lacking. Many expressed the opinion that ALK- ALCL is not a distinct entity at the immunophenotypic or genetic level and is better designated as peripheral T-cell lymphoma (PTCL), unspecified. Others suggested that the histologic features of ALK- ALCL are distinctive nevertheless and that this diagnosis has meaning that is lost by designating these neoplasms as PTCL, unspecified. This session also included CD30+ anaplastic lymphomas involving skin in which the differential diagnosis included cutaneous ALCL and systemic ALK- ALCL.
Original language | English (US) |
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Pages (from-to) | 707-722 |
Number of pages | 16 |
Journal | American journal of clinical pathology |
Volume | 127 |
Issue number | 5 |
DOIs | |
State | Published - May 2007 |
Keywords
- Anaplastic large cell lymphoma
- Anaplastic lymphoma kinase
- Classical Hodgkin lymphoma
- Peripheral T-cell lymphoma
ASJC Scopus subject areas
- Pathology and Forensic Medicine