Abstract
High-resolution echo-planar spectroscopic imaging (EPSI) of water resonance (i.e. without water suppression) is proposed for anatomic and functional imaging of the human brain at 1.5 T. Water spectra with a resolution of 2.6 Hz and a bandwidth of 333 Hz were obtained in small voxels (1.7 × 1.7 × 3 mm3) across a single slice. Although water spectra appeared Lorentzian in most of the voxels in the brain, non-Lorentzian broadening of the water resonance was observed in voxels containing blood vessels. In functional experiments with a motor task, robust activation in motor cortices was observed in high-resolution T2* maps generated from the EPSI data. Shift of the water resonance frequency occurred during neuronal activation in motor cortices. The activation areas appeared to be more localized after excluding the voxels in which the lineshape of the water resonance had elevated T2* and became more non-Lorentzian during the motor task. These preliminary results suggest that high-resolution EPSI is a promising tool to study susceptibility-related effects, such as BOLD contrast. for improved anatomical and functional imaging of the brain.
Original language | English (US) |
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Pages (from-to) | 235-241 |
Number of pages | 7 |
Journal | NMR in Biomedicine |
Volume | 18 |
Issue number | 4 |
DOIs | |
State | Published - Jun 2005 |
Externally published | Yes |
Keywords
- Echo-planar spectroscopic imaging
- Magnetic resonance spectroscopic imaging
- Water resonance
- fMRI
ASJC Scopus subject areas
- Molecular Medicine
- Radiology Nuclear Medicine and imaging
- Spectroscopy