Androgen receptor polymorphisms and risk of biochemical failure among prostatectomy patients

Sara S. Strom; Yun Gu; Hui Zhang; Patricia Troncoso; Richard J. Babaian; Curtis A. Pettaway; Sanjay Shete; Margaret R. Spitz; Christopher J. Logothetis

doi:10.1002/pros.20060

Androgen receptor polymorphisms and risk of biochemical failure among prostatectomy patients

Sara S. Strom, Yun Gu, Hui Zhang, Patricia Troncoso, Richard J. Babaian, Curtis A. Pettaway, Sanjay Shete, Margaret R. Spitz, Christopher J. Logothetis

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

BACKGROUND. Little is known about the role of inherited genotypes in prostate cancer (PC) progression. This prospective study evaluated the predictive value of androgen receptor (AR) polymorphisms (CAG and GGC repeats) among prostatectomy patients. METHODS. We studied 354 patients registered at M. D. Anderson Cancer Center from 1991 to 2001. Kaplan-Meier and Cox proportional hazard analyses were used. RESULTS. During an average follow-up of 56 months, 66 (19%) post-prostatectomy patients experienced biochemical failure (BF). Patients with higher CAG repeats (CAG ≥ 24) had significantly longer BF-free survival (BFFS) than those with fewer repeats (CAG ≤ 23) (P = 0.04). Higher CAG repeats were significantly associated with lower BF risk among Whites and African Americans. Among Whites, longer CAG repeats (relative risk (RR) = 0.45, P = 0.03) and Gleason score ≥8 (RR = 19.33, P = 0.005) remained significant BFFS predictors in multivariate analysis. GGC repeats were not associated with BF. CONCLUSIONS. Our data showed that an inherited polymorphism (CAG repeats) in the AR is related to differences in genetic susceptibility to BF, supporting the hypothesis that increased AR activity may play a role in PC progression.

Original language	English (US)
Pages (from-to)	343-351
Number of pages	9
Journal	Prostate
Volume	60
Issue number	4
DOIs	https://doi.org/10.1002/pros.20060
State	Published - Sep 1 2004

Keywords

Androgen receptor
CAG and GGC repeats
Progression
Prostate cancer

ASJC Scopus subject areas

Oncology
Urology

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10.1002/pros.20060

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title = "Androgen receptor polymorphisms and risk of biochemical failure among prostatectomy patients",

abstract = "BACKGROUND. Little is known about the role of inherited genotypes in prostate cancer (PC) progression. This prospective study evaluated the predictive value of androgen receptor (AR) polymorphisms (CAG and GGC repeats) among prostatectomy patients. METHODS. We studied 354 patients registered at M. D. Anderson Cancer Center from 1991 to 2001. Kaplan-Meier and Cox proportional hazard analyses were used. RESULTS. During an average follow-up of 56 months, 66 (19%) post-prostatectomy patients experienced biochemical failure (BF). Patients with higher CAG repeats (CAG ≥ 24) had significantly longer BF-free survival (BFFS) than those with fewer repeats (CAG ≤ 23) (P = 0.04). Higher CAG repeats were significantly associated with lower BF risk among Whites and African Americans. Among Whites, longer CAG repeats (relative risk (RR) = 0.45, P = 0.03) and Gleason score ≥8 (RR = 19.33, P = 0.005) remained significant BFFS predictors in multivariate analysis. GGC repeats were not associated with BF. CONCLUSIONS. Our data showed that an inherited polymorphism (CAG repeats) in the AR is related to differences in genetic susceptibility to BF, supporting the hypothesis that increased AR activity may play a role in PC progression.",

keywords = "Androgen receptor, CAG and GGC repeats, Progression, Prostate cancer",

author = "Strom, {Sara S.} and Yun Gu and Hui Zhang and Patricia Troncoso and Babaian, {Richard J.} and Pettaway, {Curtis A.} and Sanjay Shete and Spitz, {Margaret R.} and Logothetis, {Christopher J.}",

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T1 - Androgen receptor polymorphisms and risk of biochemical failure among prostatectomy patients

AU - Strom, Sara S.

AU - Gu, Yun

AU - Zhang, Hui

AU - Troncoso, Patricia

AU - Babaian, Richard J.

AU - Pettaway, Curtis A.

AU - Shete, Sanjay

AU - Spitz, Margaret R.

AU - Logothetis, Christopher J.

PY - 2004/9/1

Y1 - 2004/9/1

N2 - BACKGROUND. Little is known about the role of inherited genotypes in prostate cancer (PC) progression. This prospective study evaluated the predictive value of androgen receptor (AR) polymorphisms (CAG and GGC repeats) among prostatectomy patients. METHODS. We studied 354 patients registered at M. D. Anderson Cancer Center from 1991 to 2001. Kaplan-Meier and Cox proportional hazard analyses were used. RESULTS. During an average follow-up of 56 months, 66 (19%) post-prostatectomy patients experienced biochemical failure (BF). Patients with higher CAG repeats (CAG ≥ 24) had significantly longer BF-free survival (BFFS) than those with fewer repeats (CAG ≤ 23) (P = 0.04). Higher CAG repeats were significantly associated with lower BF risk among Whites and African Americans. Among Whites, longer CAG repeats (relative risk (RR) = 0.45, P = 0.03) and Gleason score ≥8 (RR = 19.33, P = 0.005) remained significant BFFS predictors in multivariate analysis. GGC repeats were not associated with BF. CONCLUSIONS. Our data showed that an inherited polymorphism (CAG repeats) in the AR is related to differences in genetic susceptibility to BF, supporting the hypothesis that increased AR activity may play a role in PC progression.

AB - BACKGROUND. Little is known about the role of inherited genotypes in prostate cancer (PC) progression. This prospective study evaluated the predictive value of androgen receptor (AR) polymorphisms (CAG and GGC repeats) among prostatectomy patients. METHODS. We studied 354 patients registered at M. D. Anderson Cancer Center from 1991 to 2001. Kaplan-Meier and Cox proportional hazard analyses were used. RESULTS. During an average follow-up of 56 months, 66 (19%) post-prostatectomy patients experienced biochemical failure (BF). Patients with higher CAG repeats (CAG ≥ 24) had significantly longer BF-free survival (BFFS) than those with fewer repeats (CAG ≤ 23) (P = 0.04). Higher CAG repeats were significantly associated with lower BF risk among Whites and African Americans. Among Whites, longer CAG repeats (relative risk (RR) = 0.45, P = 0.03) and Gleason score ≥8 (RR = 19.33, P = 0.005) remained significant BFFS predictors in multivariate analysis. GGC repeats were not associated with BF. CONCLUSIONS. Our data showed that an inherited polymorphism (CAG repeats) in the AR is related to differences in genetic susceptibility to BF, supporting the hypothesis that increased AR activity may play a role in PC progression.

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KW - Progression

KW - Prostate cancer

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Androgen receptor polymorphisms and risk of biochemical failure among prostatectomy patients

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