Angiogenesis as a strategic target for ovarian cancer therapy

Whitney A. Spannuth; Anil K. Sood; Robert L. Coleman

doi:10.1038/ncponc1051

Angiogenesis as a strategic target for ovarian cancer therapy

Whitney A. Spannuth, Anil K. Sood, Robert L. Coleman

Gynecological Oncology & Reproductive Medicine

Research output: Contribution to journal › Review article › peer-review

134 Scopus citations

Abstract

Angiogenesis is a complex and highly regulated process that is crucial for tumor growth and metastasis. Insights into the molecular mechanisms of tumor angiogenesis have led to the identification of potential angiogenic targets and the development of novel antivascular agents. Many of these agents are being evaluated in clinical trials and have shown promising antitumor activity. This Review highlights the results of the latest clinical studies of antivascular agents in ovarian cancer and discusses the challenges and opportunities for future clinical trials.

Original language	English (US)
Pages (from-to)	194-204
Number of pages	11
Journal	Nature Clinical Practice Oncology
Volume	5
Issue number	4
DOIs	https://doi.org/10.1038/ncponc1051
State	Published - Apr 2008

ASJC Scopus subject areas

Oncology

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10.1038/ncponc1051

Cite this

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AB - Angiogenesis is a complex and highly regulated process that is crucial for tumor growth and metastasis. Insights into the molecular mechanisms of tumor angiogenesis have led to the identification of potential angiogenic targets and the development of novel antivascular agents. Many of these agents are being evaluated in clinical trials and have shown promising antitumor activity. This Review highlights the results of the latest clinical studies of antivascular agents in ovarian cancer and discusses the challenges and opportunities for future clinical trials.

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Angiogenesis as a strategic target for ovarian cancer therapy

Abstract

ASJC Scopus subject areas

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