TY - JOUR
T1 - Animal models of renal fibrosis.
AU - Zeisberg, Michael
AU - Soubasakos, Mary A.
AU - Kalluri, Raghu
N1 - Copyright:
This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine
PY - 2005
Y1 - 2005
N2 - Most of the present knowledge on pathomechanism of renal fibrosis is based on experimental studies with laboratory animals. Today, a variety of genetic and inducible animal models that mimic primary causes of human disease such as diabetes mellitus, glomerulonephritis, or lupus erythematodes are available. However, only few of these models progress consistently to interstitial fibrosis in the kidney involving interestitial fibrosis, tubular atrophy, and glomerulosclerosis, which are common features of renal fibrogenesis. In this chapter, the mouse models of nephrotoxic serum nephritis, COL4A3-deficiency, and unilateral urethral obstruction, which all result reliably into renal fibrosis, are described.
AB - Most of the present knowledge on pathomechanism of renal fibrosis is based on experimental studies with laboratory animals. Today, a variety of genetic and inducible animal models that mimic primary causes of human disease such as diabetes mellitus, glomerulonephritis, or lupus erythematodes are available. However, only few of these models progress consistently to interstitial fibrosis in the kidney involving interestitial fibrosis, tubular atrophy, and glomerulosclerosis, which are common features of renal fibrogenesis. In this chapter, the mouse models of nephrotoxic serum nephritis, COL4A3-deficiency, and unilateral urethral obstruction, which all result reliably into renal fibrosis, are described.
UR - http://www.scopus.com/inward/record.url?scp=24944436751&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=24944436751&partnerID=8YFLogxK
U2 - 10.1385/1-59259-940-0:261
DO - 10.1385/1-59259-940-0:261
M3 - Article
C2 - 16118458
AN - SCOPUS:24944436751
SN - 1543-1894
VL - 117
SP - 261
EP - 272
JO - Methods in molecular medicine
JF - Methods in molecular medicine
ER -