TY - JOUR
T1 - Anti-inflammatory, analgesic and antioxidant activities of novel kyotorphin-nitroxide hybrid molecules
AU - Bi, Wei
AU - Bi, Yue
AU - Gao, Xiang
AU - Yan, Xin
AU - Zhang, Yanrong
AU - Xue, Ping
AU - Bammert, Catherine E.
AU - Legalley, Thomas D.
AU - Michael Gibson, K.
AU - Bi, Lanrong
AU - Wang, Jia Xiang
N1 - Funding Information:
The authors acknowledge the support of NIH ( GM088795-01 ), NSF (No. 1048655 ), NASA (# MSGC R85197 ), MIIE (# 1204010 ), VPR-SI fund (# R01386 ), and the Research Excellence Fund (# R01121 and # R01323 ), National Science Foundation of China (No. 81370419 ), Natural Science Foundation of HeBei , China (Grant 062761266 ), Administration of Traditional Chinese Medicine of HeBei Province (Grant 2007134 ). The authors are particularly thankful to Dr. Bruce Seely for his on-going support of our work.
PY - 2016/4/15
Y1 - 2016/4/15
N2 - Mitochondrial oxidative damage contributes to a wide range of pathologies, including ischemia/reperfusion (I/R) injury, cardiovascular disorders and neurodegenerative diseases. Accordingly, protecting mitochondria from oxidative damage should possess therapeutic relevance. In the present study, we have designed and synthesized a series of novel kyotorphin-nitroxide hybrid molecules, and examined their free radical scavenging activities, in addition to their anti-inflammatory and analgesic activities. We have further characterized these compounds in a simulated I/R cellular model. Our findings suggest that the protective effects of kyotorphin-nitroxides partially reside in maintaining optimal mitochondrial function.
AB - Mitochondrial oxidative damage contributes to a wide range of pathologies, including ischemia/reperfusion (I/R) injury, cardiovascular disorders and neurodegenerative diseases. Accordingly, protecting mitochondria from oxidative damage should possess therapeutic relevance. In the present study, we have designed and synthesized a series of novel kyotorphin-nitroxide hybrid molecules, and examined their free radical scavenging activities, in addition to their anti-inflammatory and analgesic activities. We have further characterized these compounds in a simulated I/R cellular model. Our findings suggest that the protective effects of kyotorphin-nitroxides partially reside in maintaining optimal mitochondrial function.
KW - Analgesic activity
KW - Anti-inflammatory activity
KW - Free radical scavenging activity
KW - Ischemia/reperfusion injury
KW - Kyotorphin-nitroxide hybrid molecules
UR - http://www.scopus.com/inward/record.url?scp=84959541611&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84959541611&partnerID=8YFLogxK
U2 - 10.1016/j.bmcl.2016.02.086
DO - 10.1016/j.bmcl.2016.02.086
M3 - Article
C2 - 26961795
AN - SCOPUS:84959541611
SN - 0960-894X
VL - 26
SP - 2005
EP - 2013
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 8
ER -