Antibody regulation of B cell development

Eric Meffre; Rafael Casellas; Michel C. Nussenzweig

doi:10.1038/80816

Antibody regulation of B cell development

Eric Meffre, Rafael Casellas, Michel C. Nussenzweig

Research output: Contribution to journal › Review article › peer-review

206 Scopus citations

Abstract

Antibodies on the surface of B lymphocytes trigger adaptive immune responses and control a series of antigen-independent checkpoints during B cell development. These physiologic processes are regulated by a complex of membrane immunoglobulin and two signal transducing proteins known as Igα and Igβ. Here we focus on the role of antibodies in governing the maturation of B cells from early antigen-independent through the final antigen-dependent stages.

Original language	English (US)
Pages (from-to)	379-385
Number of pages	7
Journal	Nature Immunology
Volume	1
Issue number	5
DOIs	https://doi.org/10.1038/80816
State	Published - Nov 2000
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1038/80816

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title = "Antibody regulation of B cell development",

abstract = "Antibodies on the surface of B lymphocytes trigger adaptive immune responses and control a series of antigen-independent checkpoints during B cell development. These physiologic processes are regulated by a complex of membrane immunoglobulin and two signal transducing proteins known as Igα and Igβ. Here we focus on the role of antibodies in governing the maturation of B cells from early antigen-independent through the final antigen-dependent stages.",

author = "Eric Meffre and Rafael Casellas and Nussenzweig, {Michel C.}",

year = "2000",

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doi = "10.1038/80816",

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AU - Casellas, Rafael

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AB - Antibodies on the surface of B lymphocytes trigger adaptive immune responses and control a series of antigen-independent checkpoints during B cell development. These physiologic processes are regulated by a complex of membrane immunoglobulin and two signal transducing proteins known as Igα and Igβ. Here we focus on the role of antibodies in governing the maturation of B cells from early antigen-independent through the final antigen-dependent stages.

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M3 - Review article

C2 - 11062496

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Antibody regulation of B cell development

Abstract

ASJC Scopus subject areas

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