TY - JOUR
T1 - Antidepressant-like activity of dehydrozingerone
T2 - Involvement of the serotonergic and noradrenergic systems
AU - Martinez, Débora M.
AU - Barcellos, Angelita
AU - Casaril, Angela M.
AU - Savegnago, Lucielli
AU - Lernardão, Eder J.
N1 - Publisher Copyright:
© 2014, Elsevier Inc. All rights reserved.
PY - 2014/12
Y1 - 2014/12
N2 - Dehydrozingerone (DHZ) is a phenolic compound isolated from ginger rhizomes (Zingiber officinale). It is known for its diverse spectrum of biological activities as an antioxidant, anti-inflammatory and antitumor compound. The present study was designed to assess the antidepressant effect of DHZ and the involvement of the monoaminergic system and to evaluate its in vitro antioxidant activity in the hippocampus, cortex and cerebellum of mice. For this study, the tail suspension test (TST), forced swim test (FST) and yohimbine lethality test were performed. DHZ administered orally 30 min prior to testing reduced the immobility time in the TST (1-40 mg/kg) and the FST (10-40 mg/kg), with no change in locomotor activity in the open field test. The antidepressant-like effect of DHZ (1 mg/kg) was prevented by ketanserin (1 mg/kg, i.p.; a 5-HT2A/2C receptor antagonist), ondansetron (1 mg/kg, i.p.; a 5-HT3 receptor antagonist), prazosin (1 mg/kg, i.p., an α1-adrenoceptor antagonist) and yohimbine (1 mg/kg, i.p., an α2-adrenoceptor antagonist) pretreatments. Furthermore, DHZ administered at doses of 10 and 20 mg/kg increased the lethality of yohimbine (35 mg/kg, i.p.). DHZ had antioxidant activity on in vitro lipid peroxidation induced by sodium nitroprusside in all brain regions tested. The results revealed that DHZ has a potent antidepressant effect, which seems to involve the serotonergic and noradrenergic systems.
AB - Dehydrozingerone (DHZ) is a phenolic compound isolated from ginger rhizomes (Zingiber officinale). It is known for its diverse spectrum of biological activities as an antioxidant, anti-inflammatory and antitumor compound. The present study was designed to assess the antidepressant effect of DHZ and the involvement of the monoaminergic system and to evaluate its in vitro antioxidant activity in the hippocampus, cortex and cerebellum of mice. For this study, the tail suspension test (TST), forced swim test (FST) and yohimbine lethality test were performed. DHZ administered orally 30 min prior to testing reduced the immobility time in the TST (1-40 mg/kg) and the FST (10-40 mg/kg), with no change in locomotor activity in the open field test. The antidepressant-like effect of DHZ (1 mg/kg) was prevented by ketanserin (1 mg/kg, i.p.; a 5-HT2A/2C receptor antagonist), ondansetron (1 mg/kg, i.p.; a 5-HT3 receptor antagonist), prazosin (1 mg/kg, i.p., an α1-adrenoceptor antagonist) and yohimbine (1 mg/kg, i.p., an α2-adrenoceptor antagonist) pretreatments. Furthermore, DHZ administered at doses of 10 and 20 mg/kg increased the lethality of yohimbine (35 mg/kg, i.p.). DHZ had antioxidant activity on in vitro lipid peroxidation induced by sodium nitroprusside in all brain regions tested. The results revealed that DHZ has a potent antidepressant effect, which seems to involve the serotonergic and noradrenergic systems.
KW - Antidepressant
KW - Antioxidant
KW - Dehydrozingerone
KW - Monoaminergic system
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U2 - 10.1016/j.pbb.2014.10.010
DO - 10.1016/j.pbb.2014.10.010
M3 - Article
C2 - 25449795
AN - SCOPUS:84911402959
SN - 0091-3057
VL - 127
SP - 111
EP - 117
JO - Pharmacology Biochemistry and Behavior
JF - Pharmacology Biochemistry and Behavior
ER -