Antielastin autoimmunity in tobacco smoking-induced emphysema

Seung Hyo Lee; Sangeeta Goswami; Ariel Grudo; Li Zhen Song; Venkata Bandi; Sheila Goodnight-White; Linda Green; Joan Hacken-Bitar; Joseph Huh; Faisal Bakaeen; Harvey O. Coxson; Sebastian Cogswell; Claudine Storness-Bliss; David B. Corry; Farrah Kheradmand

doi:10.1038/nm1583

Antielastin autoimmunity in tobacco smoking-induced emphysema

Seung Hyo Lee, Sangeeta Goswami, Ariel Grudo, Li Zhen Song, Venkata Bandi, Sheila Goodnight-White, Linda Green, Joan Hacken-Bitar, Joseph Huh, Faisal Bakaeen, Harvey O. Coxson, Sebastian Cogswell, Claudine Storness-Bliss, David B. Corry, Farrah Kheradmand

Research output: Contribution to journal › Article › peer-review

483 Scopus citations

Abstract

Chronic obstructive pulmonary disease and emphysema are common destructive inflammatory diseases that are leading causes of death worldwide. Here we show that emphysema is an autoimmune disease characterized by the presence of antielastin antibody and T-helper type 1 (T_H1) responses, which correlate with emphysema severity. These findings link emphysema to adaptive immunity against a specific lung antigen and suggest the potential for autoimmune pathology of other elastin-rich tissues such as the arteries and skin of smokers.

Original language	English (US)
Pages (from-to)	567-569
Number of pages	3
Journal	Nature medicine
Volume	13
Issue number	5
DOIs	https://doi.org/10.1038/nm1583
State	Published - May 2007
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1038/nm1583

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title = "Antielastin autoimmunity in tobacco smoking-induced emphysema",

abstract = "Chronic obstructive pulmonary disease and emphysema are common destructive inflammatory diseases that are leading causes of death worldwide. Here we show that emphysema is an autoimmune disease characterized by the presence of antielastin antibody and T-helper type 1 (TH1) responses, which correlate with emphysema severity. These findings link emphysema to adaptive immunity against a specific lung antigen and suggest the potential for autoimmune pathology of other elastin-rich tissues such as the arteries and skin of smokers.",

author = "Lee, {Seung Hyo} and Sangeeta Goswami and Ariel Grudo and Song, {Li Zhen} and Venkata Bandi and Sheila Goodnight-White and Linda Green and Joan Hacken-Bitar and Joseph Huh and Faisal Bakaeen and Coxson, {Harvey O.} and Sebastian Cogswell and Claudine Storness-Bliss and Corry, {David B.} and Farrah Kheradmand",

note = "Funding Information: We thank D. Spencer and B. Zheng for their comments, and R. Wang (Baylor College of Medicine) for providing antibodies to HLA. We thank P. Smithwick, S. Perusich, R. Williams and N. Hanania for their assistance in recruiting subjects. Supported by grants to F.K. and D.B.C. from the US National Institutes of Health and the Alpha 1 Foundation.",

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doi = "10.1038/nm1583",

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AU - Lee, Seung Hyo

AU - Goswami, Sangeeta

AU - Grudo, Ariel

AU - Song, Li Zhen

AU - Bandi, Venkata

AU - Goodnight-White, Sheila

AU - Green, Linda

AU - Hacken-Bitar, Joan

AU - Huh, Joseph

AU - Bakaeen, Faisal

AU - Coxson, Harvey O.

AU - Cogswell, Sebastian

AU - Storness-Bliss, Claudine

AU - Corry, David B.

AU - Kheradmand, Farrah

N1 - Funding Information: We thank D. Spencer and B. Zheng for their comments, and R. Wang (Baylor College of Medicine) for providing antibodies to HLA. We thank P. Smithwick, S. Perusich, R. Williams and N. Hanania for their assistance in recruiting subjects. Supported by grants to F.K. and D.B.C. from the US National Institutes of Health and the Alpha 1 Foundation.

PY - 2007/5

Y1 - 2007/5

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AB - Chronic obstructive pulmonary disease and emphysema are common destructive inflammatory diseases that are leading causes of death worldwide. Here we show that emphysema is an autoimmune disease characterized by the presence of antielastin antibody and T-helper type 1 (TH1) responses, which correlate with emphysema severity. These findings link emphysema to adaptive immunity against a specific lung antigen and suggest the potential for autoimmune pathology of other elastin-rich tissues such as the arteries and skin of smokers.

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Antielastin autoimmunity in tobacco smoking-induced emphysema

Abstract

ASJC Scopus subject areas

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