TY - JOUR
T1 - Antiestrogen therapy for breast cancer
T2 - current strategies and future prospects.
AU - Jordan, V. C.
AU - Tormey, D. C.
N1 - Copyright:
This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine
PY - 1988
Y1 - 1988
N2 - The antiestrogen tamoxifen has had an enormous impact upon the therapy of breast cancer. It is the most widely used antihormonal therapy. The success of tamoxifen has stimulated broader applications of the drug (long-term adjuvant therapy and chemosuppression) and has spurred the development of toremifene, droloxifene, and zindoxifene. However, the clinical evaluation of tamoxifen as a chemosuppressive agent is not sufficiently advanced to be able to provide any conclusion about the success of this strategy. It may be a decade before a randomized clinical study can be analyzed and the value of chemosuppression assessed. In the near future, the clinical evaluation of new antiestrogens will provide additional information about the potential value of these drugs and will perhaps challenge our ideas about the mode of action of antiestrogens as antitumor agents.
AB - The antiestrogen tamoxifen has had an enormous impact upon the therapy of breast cancer. It is the most widely used antihormonal therapy. The success of tamoxifen has stimulated broader applications of the drug (long-term adjuvant therapy and chemosuppression) and has spurred the development of toremifene, droloxifene, and zindoxifene. However, the clinical evaluation of tamoxifen as a chemosuppressive agent is not sufficiently advanced to be able to provide any conclusion about the success of this strategy. It may be a decade before a randomized clinical study can be analyzed and the value of chemosuppression assessed. In the near future, the clinical evaluation of new antiestrogens will provide additional information about the potential value of these drugs and will perhaps challenge our ideas about the mode of action of antiestrogens as antitumor agents.
UR - http://www.scopus.com/inward/record.url?scp=0024145540&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024145540&partnerID=8YFLogxK
U2 - 10.1007/978-1-4613-1731-9_7
DO - 10.1007/978-1-4613-1731-9_7
M3 - Review article
C2 - 2908611
AN - SCOPUS:0024145540
SN - 0927-3042
VL - 39
SP - 97
EP - 110
JO - Cancer treatment and research
JF - Cancer treatment and research
ER -