Antigenic Determinant(s) Shared by the Human Thy 1 and Human IgG

L. Bonewald; A. C. Wang; I. Y. Wang; C. M. Balch; E. W. Ades

doi:10.1016/S0171-2985(84)80020-0

Antigenic Determinant(s) Shared by the Human Thy 1 and Human IgG

L. Bonewald, A. C. Wang, I. Y. Wang, C. M. Balch, E. W. Ades

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

A human T cell differentiation antigen (p25) previously described as being the mouse theta equivalent has been examined for shared antigenic determinants with immunoglobulin. A strong cross-reactivity of an antiserum prepared against p25 antigen was established with human IgG subclasses. This antiserum does not react with human IgM or IgA, nor with primate immunoglobulins. The shared determinants appear to be associated with the disulphide-bonded cysteines in the first and third constant domains of the IgG molecule and the 9–112 disulfide bond of Thy 1.

Original language	English (US)
Pages (from-to)	428-438
Number of pages	11
Journal	Immunobiology
Volume	166
Issue number	4-5
DOIs	https://doi.org/10.1016/S0171-2985(84)80020-0
State	Published - 1984
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Hematology

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10.1016/S0171-2985(84)80020-0

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title = "Antigenic Determinant(s) Shared by the Human Thy 1 and Human IgG",

abstract = "A human T cell differentiation antigen (p25) previously described as being the mouse theta equivalent has been examined for shared antigenic determinants with immunoglobulin. A strong cross-reactivity of an antiserum prepared against p25 antigen was established with human IgG subclasses. This antiserum does not react with human IgM or IgA, nor with primate immunoglobulins. The shared determinants appear to be associated with the disulphide-bonded cysteines in the first and third constant domains of the IgG molecule and the 9–112 disulfide bond of Thy 1.",

author = "L. Bonewald and Wang, {A. C.} and Wang, {I. Y.} and Balch, {C. M.} and Ades, {E. W.}",

note = "Funding Information: Publication no. 656 from the Department of Basic and Clinical Immunology and Microbiology. Medical University of South Carolina. Research supported in part by National Cancer Institute, DHHS grant CA-34900, National Science Foundation Grant PCM-82-017S7 and South Carolina State Appropriation Grant CR-10.",

year = "1984",

doi = "10.1016/S0171-2985(84)80020-0",

language = "English (US)",

volume = "166",

pages = "428--438",

journal = "Immunobiology",

issn = "0171-2985",

publisher = "American Society of Hematology",

number = "4-5",

}

TY - JOUR

T1 - Antigenic Determinant(s) Shared by the Human Thy 1 and Human IgG

AU - Bonewald, L.

AU - Wang, A. C.

AU - Wang, I. Y.

AU - Balch, C. M.

AU - Ades, E. W.

N1 - Funding Information: Publication no. 656 from the Department of Basic and Clinical Immunology and Microbiology. Medical University of South Carolina. Research supported in part by National Cancer Institute, DHHS grant CA-34900, National Science Foundation Grant PCM-82-017S7 and South Carolina State Appropriation Grant CR-10.

PY - 1984

Y1 - 1984

N2 - A human T cell differentiation antigen (p25) previously described as being the mouse theta equivalent has been examined for shared antigenic determinants with immunoglobulin. A strong cross-reactivity of an antiserum prepared against p25 antigen was established with human IgG subclasses. This antiserum does not react with human IgM or IgA, nor with primate immunoglobulins. The shared determinants appear to be associated with the disulphide-bonded cysteines in the first and third constant domains of the IgG molecule and the 9–112 disulfide bond of Thy 1.

AB - A human T cell differentiation antigen (p25) previously described as being the mouse theta equivalent has been examined for shared antigenic determinants with immunoglobulin. A strong cross-reactivity of an antiserum prepared against p25 antigen was established with human IgG subclasses. This antiserum does not react with human IgM or IgA, nor with primate immunoglobulins. The shared determinants appear to be associated with the disulphide-bonded cysteines in the first and third constant domains of the IgG molecule and the 9–112 disulfide bond of Thy 1.

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DO - 10.1016/S0171-2985(84)80020-0

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JO - Immunobiology

JF - Immunobiology

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ER -

Antigenic Determinant(s) Shared by the Human Thy 1 and Human IgG

Abstract

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