Antiproliferative and teratogenic activities of the bishemisuccinates of 7α-hydroxycholesterol and 7β-hydroxycholesterol

W. Y. Chan; T. B. Ng; S. H. Rong; H. W. Yeung; S. C. Mok

doi:10.1016/0306-3623(94)90258-5

Antiproliferative and teratogenic activities of the bishemisuccinates of 7α-hydroxycholesterol and 7β-hydroxycholesterol

W. Y. Chan, T. B. Ng, S. H. Rong, H. W. Yeung, S. C. Mok

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

1. The bishemisuccinates of 7α-hydroxycholesterol and 7β-hydroxycholesterol induced a dose-dependent decrease in the incorporation of [³H]thymidine into fibroblast cell line (3T3), macrophagelike cell line (P388D1) and rat hepatoma cell line (H35). Concomitantly there was a reduction in cell viability. 2. The 3T3 cells were less susceptible than P388D1 and H35 cells. 3. The aforementioned derivatives of 7α-hydroxycholesterol and 7β-hydroxycholesterol produced malformations in cultured embryos including abnormalities in yolk sac circulation, heartbeat, body axis, otic vesicle, branchial apparatus, cranial neural tube and forelimb bud. Axial length and somite number were reduced.

Original language	English (US)
Pages (from-to)	767-772
Number of pages	6
Journal	General Pharmacology
Volume	25
Issue number	4
DOIs	https://doi.org/10.1016/0306-3623(94)90258-5
State	Published - Jul 1994
Externally published	Yes

Keywords

Sodium bishemisuccinate oxysterols
development
fibroblast cell line 3T3
hepatoma cell line H35
macrophage cell line P388D1

ASJC Scopus subject areas

Pharmacology

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10.1016/0306-3623(94)90258-5

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title = "Antiproliferative and teratogenic activities of the bishemisuccinates of 7α-hydroxycholesterol and 7β-hydroxycholesterol",

abstract = "1. The bishemisuccinates of 7α-hydroxycholesterol and 7β-hydroxycholesterol induced a dose-dependent decrease in the incorporation of [3H]thymidine into fibroblast cell line (3T3), macrophagelike cell line (P388D1) and rat hepatoma cell line (H35). Concomitantly there was a reduction in cell viability. 2. The 3T3 cells were less susceptible than P388D1 and H35 cells. 3. The aforementioned derivatives of 7α-hydroxycholesterol and 7β-hydroxycholesterol produced malformations in cultured embryos including abnormalities in yolk sac circulation, heartbeat, body axis, otic vesicle, branchial apparatus, cranial neural tube and forelimb bud. Axial length and somite number were reduced.",

keywords = "Sodium bishemisuccinate oxysterols, development, fibroblast cell line 3T3, hepatoma cell line H35, macrophage cell line P388D1",

author = "Chan, {W. Y.} and Ng, {T. B.} and Rong, {S. H.} and Yeung, {H. W.} and Mok, {S. C.}",

year = "1994",

month = jul,

doi = "10.1016/0306-3623(94)90258-5",

language = "English (US)",

volume = "25",

pages = "767--772",

journal = "General Pharmacology",

issn = "0306-3623",

publisher = "Elsevier Inc.",

number = "4",

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TY - JOUR

T1 - Antiproliferative and teratogenic activities of the bishemisuccinates of 7α-hydroxycholesterol and 7β-hydroxycholesterol

AU - Chan, W. Y.

AU - Ng, T. B.

AU - Rong, S. H.

AU - Yeung, H. W.

AU - Mok, S. C.

PY - 1994/7

Y1 - 1994/7

N2 - 1. The bishemisuccinates of 7α-hydroxycholesterol and 7β-hydroxycholesterol induced a dose-dependent decrease in the incorporation of [3H]thymidine into fibroblast cell line (3T3), macrophagelike cell line (P388D1) and rat hepatoma cell line (H35). Concomitantly there was a reduction in cell viability. 2. The 3T3 cells were less susceptible than P388D1 and H35 cells. 3. The aforementioned derivatives of 7α-hydroxycholesterol and 7β-hydroxycholesterol produced malformations in cultured embryos including abnormalities in yolk sac circulation, heartbeat, body axis, otic vesicle, branchial apparatus, cranial neural tube and forelimb bud. Axial length and somite number were reduced.

AB - 1. The bishemisuccinates of 7α-hydroxycholesterol and 7β-hydroxycholesterol induced a dose-dependent decrease in the incorporation of [3H]thymidine into fibroblast cell line (3T3), macrophagelike cell line (P388D1) and rat hepatoma cell line (H35). Concomitantly there was a reduction in cell viability. 2. The 3T3 cells were less susceptible than P388D1 and H35 cells. 3. The aforementioned derivatives of 7α-hydroxycholesterol and 7β-hydroxycholesterol produced malformations in cultured embryos including abnormalities in yolk sac circulation, heartbeat, body axis, otic vesicle, branchial apparatus, cranial neural tube and forelimb bud. Axial length and somite number were reduced.

KW - Sodium bishemisuccinate oxysterols

KW - development

KW - fibroblast cell line 3T3

KW - hepatoma cell line H35

KW - macrophage cell line P388D1

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U2 - 10.1016/0306-3623(94)90258-5

DO - 10.1016/0306-3623(94)90258-5

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AN - SCOPUS:0028319063

SN - 0306-3623

VL - 25

SP - 767

EP - 772

JO - General Pharmacology

JF - General Pharmacology

IS - 4

ER -

Antiproliferative and teratogenic activities of the bishemisuccinates of 7α-hydroxycholesterol and 7β-hydroxycholesterol

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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