Abstract
(HIDP). Fresh human tumor samples in the adhesive tumor culture system were utilized for this comparison. The eqidtoxic concentrations of all four drugs were derived based on their inhibitory activity against human bone marrow samples. For these normalized concentrations, CDDP proved to have a higher cytotoxic activity than its analogues. CBDCA's in vitro activity had a significant correlation with CDDP activity (r = 0.67) in vitro. However, the structurally similar substances MIDP and HIDP demonstrated a much greater degree of association (r = 0.90). Our data suggest that CBDCA, HIDP, and MIDP have overall less activity than CDDP when tested at equitoxic in vitro concentrations. Close association between CDDP and CBDCA also reflects known clinical experience with these two drugs, suggesting the method of comparison used here is probably appropriate. These conclusions, however, must be validated by clinical trials.
Original language | English (US) |
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Pages (from-to) | 3135-3139 |
Number of pages | 5 |
Journal | Cancer Research |
Volume | 48 |
Issue number | 11 |
State | Published - 1988 |
ASJC Scopus subject areas
- Oncology
- Cancer Research