Anxiolytics cause anxiety in pancreatic cancer

Yang Chen; Anirban Maitra

doi:10.1016/j.trecan.2023.09.005

Anxiolytics cause anxiety in pancreatic cancer

Research output: Contribution to journal › Short survey › peer-review

Abstract

Benzodiazepines (BZDs) are commonly prescribed for pancreatic cancer patients. To investigate the correlation between BZDs and survival outcomes a recent study by Cornwell et al. found that lorazepam (LOR) correlates with poor survival. The mechanistic study shows that LOR increases interleukin 6 (IL6) expression in cancer-associated fibroblasts via GPR68.

Original language	English (US)
Pages (from-to)	874-875
Number of pages	2
Journal	Trends in Cancer
Volume	9
Issue number	11
DOIs	https://doi.org/10.1016/j.trecan.2023.09.005
State	Published - Nov 2023

Keywords

benzodiazepines
fibroblast
GPR68
interleukin 6
pancreatic cancer
survival

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.trecan.2023.09.005

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title = "Anxiolytics cause anxiety in pancreatic cancer",

abstract = "Benzodiazepines (BZDs) are commonly prescribed for pancreatic cancer patients. To investigate the correlation between BZDs and survival outcomes a recent study by Cornwell et al. found that lorazepam (LOR) correlates with poor survival. The mechanistic study shows that LOR increases interleukin 6 (IL6) expression in cancer-associated fibroblasts via GPR68.",

keywords = "benzodiazepines, fibroblast, GPR68, interleukin 6, pancreatic cancer, survival",

author = "Yang Chen and Anirban Maitra",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier Inc.",

year = "2023",

month = nov,

doi = "10.1016/j.trecan.2023.09.005",

language = "English (US)",

volume = "9",

pages = "874--875",

journal = "Trends in Cancer",

issn = "2405-8033",

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TY - JOUR

T1 - Anxiolytics cause anxiety in pancreatic cancer

AU - Chen, Yang

AU - Maitra, Anirban

PY - 2023/11

Y1 - 2023/11

N2 - Benzodiazepines (BZDs) are commonly prescribed for pancreatic cancer patients. To investigate the correlation between BZDs and survival outcomes a recent study by Cornwell et al. found that lorazepam (LOR) correlates with poor survival. The mechanistic study shows that LOR increases interleukin 6 (IL6) expression in cancer-associated fibroblasts via GPR68.

AB - Benzodiazepines (BZDs) are commonly prescribed for pancreatic cancer patients. To investigate the correlation between BZDs and survival outcomes a recent study by Cornwell et al. found that lorazepam (LOR) correlates with poor survival. The mechanistic study shows that LOR increases interleukin 6 (IL6) expression in cancer-associated fibroblasts via GPR68.

KW - benzodiazepines

KW - fibroblast

KW - GPR68

KW - interleukin 6

KW - pancreatic cancer

KW - survival

UR - http://www.scopus.com/inward/record.url?scp=85172787841&partnerID=8YFLogxK

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U2 - 10.1016/j.trecan.2023.09.005

DO - 10.1016/j.trecan.2023.09.005

M3 - Short survey

C2 - 37778962

AN - SCOPUS:85172787841

SN - 2405-8033

VL - 9

SP - 874

EP - 875

JO - Trends in Cancer

JF - Trends in Cancer

IS - 11

ER -

Anxiolytics cause anxiety in pancreatic cancer

Abstract

Keywords

ASJC Scopus subject areas

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