Apobec-1 and apolipoprotein B mRNA editing

Lawrence Chan; Benny H.J. Chang; Makoto Nakamuta; Wen Hsiung Li; Louis C. Smith

doi:10.1016/S0005-2760(96)00156-7

Apobec-1 and apolipoprotein B mRNA editing

Lawrence Chan, Benny H.J. Chang, Makoto Nakamuta, Wen Hsiung Li, Louis C. Smith

Research output: Contribution to journal › Review article › peer-review

61 Scopus citations

Abstract

Apolipoprotein (apo)B mRNA editing is,a novel mechanism for the post-transcriptional regulation of gene expression in mammals. It consists of a C → U conversion of the first base of the codon CAA, encoding glutamine-2153, to UAA, an in-frame stop codon, in apoB mRNA. Since its initial description in 1987, substantial progress has been made in the last few years on the mechanism of editing. Apobec-1, the catalytic component of the apoB mRNA editing enzyme complex, has been cloned. This article begins with an overview of the general biology of apoB mRNA editing. It then provides an in-depth analysis of the structure, evolution and possible mechanism of action of apobec-1. ApoB mRNA editing is the prototype of RNA editing in mammals. What we learn from apoB mRNA editing will be useful in our understanding of other examples of RNA editing in vertebrates which are being described with increasing frequency.

Original language	English (US)
Pages (from-to)	11-26
Number of pages	16
Journal	Biochimica et Biophysica Acta - Lipids and Lipid Metabolism
Volume	1345
Issue number	1
DOIs	https://doi.org/10.1016/S0005-2760(96)00156-7
State	Published - Mar 10 1997
Externally published	Yes

Keywords

Action mechanism
Apobec-1
Apolipoprotein B
Gene expression
MRNA editing
Post-transcriptional regulation

ASJC Scopus subject areas

Biophysics
Biochemistry
Endocrinology

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10.1016/S0005-2760(96)00156-7

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title = "Apobec-1 and apolipoprotein B mRNA editing",

abstract = "Apolipoprotein (apo)B mRNA editing is,a novel mechanism for the post-transcriptional regulation of gene expression in mammals. It consists of a C → U conversion of the first base of the codon CAA, encoding glutamine-2153, to UAA, an in-frame stop codon, in apoB mRNA. Since its initial description in 1987, substantial progress has been made in the last few years on the mechanism of editing. Apobec-1, the catalytic component of the apoB mRNA editing enzyme complex, has been cloned. This article begins with an overview of the general biology of apoB mRNA editing. It then provides an in-depth analysis of the structure, evolution and possible mechanism of action of apobec-1. ApoB mRNA editing is the prototype of RNA editing in mammals. What we learn from apoB mRNA editing will be useful in our understanding of other examples of RNA editing in vertebrates which are being described with increasing frequency.",

keywords = "Action mechanism, Apobec-1, Apolipoprotein B, Gene expression, MRNA editing, Post-transcriptional regulation",

author = "Lawrence Chan and Chang, {Benny H.J.} and Makoto Nakamuta and Li, {Wen Hsiung} and Smith, {Louis C.}",

note = "Funding Information: The work described performed in the authors' laboratories was supported by U.S. National Institutes of Health grants HL-27341 and HL-56668. We thank Ms. Irene A. Harrison for her expert secretarial assistance in the preparation of this manuscript.",

year = "1997",

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doi = "10.1016/S0005-2760(96)00156-7",

language = "English (US)",

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AU - Chan, Lawrence

AU - Chang, Benny H.J.

AU - Nakamuta, Makoto

AU - Li, Wen Hsiung

AU - Smith, Louis C.

N1 - Funding Information: The work described performed in the authors' laboratories was supported by U.S. National Institutes of Health grants HL-27341 and HL-56668. We thank Ms. Irene A. Harrison for her expert secretarial assistance in the preparation of this manuscript.

PY - 1997/3/10

Y1 - 1997/3/10

N2 - Apolipoprotein (apo)B mRNA editing is,a novel mechanism for the post-transcriptional regulation of gene expression in mammals. It consists of a C → U conversion of the first base of the codon CAA, encoding glutamine-2153, to UAA, an in-frame stop codon, in apoB mRNA. Since its initial description in 1987, substantial progress has been made in the last few years on the mechanism of editing. Apobec-1, the catalytic component of the apoB mRNA editing enzyme complex, has been cloned. This article begins with an overview of the general biology of apoB mRNA editing. It then provides an in-depth analysis of the structure, evolution and possible mechanism of action of apobec-1. ApoB mRNA editing is the prototype of RNA editing in mammals. What we learn from apoB mRNA editing will be useful in our understanding of other examples of RNA editing in vertebrates which are being described with increasing frequency.

AB - Apolipoprotein (apo)B mRNA editing is,a novel mechanism for the post-transcriptional regulation of gene expression in mammals. It consists of a C → U conversion of the first base of the codon CAA, encoding glutamine-2153, to UAA, an in-frame stop codon, in apoB mRNA. Since its initial description in 1987, substantial progress has been made in the last few years on the mechanism of editing. Apobec-1, the catalytic component of the apoB mRNA editing enzyme complex, has been cloned. This article begins with an overview of the general biology of apoB mRNA editing. It then provides an in-depth analysis of the structure, evolution and possible mechanism of action of apobec-1. ApoB mRNA editing is the prototype of RNA editing in mammals. What we learn from apoB mRNA editing will be useful in our understanding of other examples of RNA editing in vertebrates which are being described with increasing frequency.

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KW - Apolipoprotein B

KW - Gene expression

KW - MRNA editing

KW - Post-transcriptional regulation

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Apobec-1 and apolipoprotein B mRNA editing

Abstract

Keywords

ASJC Scopus subject areas

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