TY - JOUR
T1 - Apolipoprotein C-II deficiency
T2 - Detection of immunoreactive apolipoprotein C-II in the intestinal mucosa of two patients
AU - Capurso, A.
AU - Mogavero, A. M.
AU - Resta, F.
AU - Di Tommaso, M.
AU - Taverniti, P.
AU - Turturro, F.
AU - La Rosa, M.
AU - Marcovina, S.
AU - Catapano, A. L.
PY - 1988
Y1 - 1988
N2 - Recent data suggest that mutant immunoreactive forms of apolipoprotein C-II (apoC-II) can be detected in the plasma of patients with the apoC-II deficiency syndrome. We studied the possible presence of apoC-II mutants in the plasma of two patients with apoC-II deficiency by immunological means. The patients were hypertriglyceridemic, and apoC-II was undetectable in plasma as determined by radial immunodiffision, electroimmunoassay, and immunonephelometry. Furthermore, apoC-II was undetectable either by electrophoresis or by immunoblotting in the plasma of the probands, while apoC-II was present in the plasma of their parents, although at less than half-normal concentration. Immunochemical localization of apoC-II, however, showed that the apoprotein could be detected within the enterocytes obtained from the intestinal mucosa of the patients. From these data we conclude that the Patients synthesize apoC-II, at least in the intestine.
AB - Recent data suggest that mutant immunoreactive forms of apolipoprotein C-II (apoC-II) can be detected in the plasma of patients with the apoC-II deficiency syndrome. We studied the possible presence of apoC-II mutants in the plasma of two patients with apoC-II deficiency by immunological means. The patients were hypertriglyceridemic, and apoC-II was undetectable in plasma as determined by radial immunodiffision, electroimmunoassay, and immunonephelometry. Furthermore, apoC-II was undetectable either by electrophoresis or by immunoblotting in the plasma of the probands, while apoC-II was present in the plasma of their parents, although at less than half-normal concentration. Immunochemical localization of apoC-II, however, showed that the apoprotein could be detected within the enterocytes obtained from the intestinal mucosa of the patients. From these data we conclude that the Patients synthesize apoC-II, at least in the intestine.
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M3 - Article
C2 - 3171393
AN - SCOPUS:0023918753
SN - 0022-2275
VL - 29
SP - 703
EP - 711
JO - Journal of lipid research
JF - Journal of lipid research
IS - 6
ER -