TY - JOUR
T1 - Appearance of acute leukemia-associated P190BCR ABL in chronic myelogenous leukemia may correlate with disease progression
AU - Dhingra, Kapil
AU - Talpaz, Moshe
AU - Kantarjian, Hagop
AU - Ku, Stella
AU - Rothberg, Jeanne
AU - Gutterman, Jordan U.
AU - Kurzrock, Razelle
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1991/3
Y1 - 1991/3
N2 - The Philadelphia translocation in chronic myelogenous leukemia (CML) results in the production of a 210 kD BCR-ABL protein. In contrast, in 50% of Philadelphia-positive acute leukemias, the translocation results in the production of a 190 kD BCR-ABL protein. To investigate the hypothesis that the production of P190 may be associated with the progression from chronic phase to blast crisis in CML, we used polymerase chain reaction to analyze blood from 37 patients with accelerated phase/blast crisis CML for the transcripts coding for the P210BCR-ABL and P190BCR-ABL. The mRNA encoding for P210 was detected in all patients. In three patients, mRNA encoding both P210 and P190 was present. In two of these three patients, samples were available from the time of initial diagnosis. Analysis of these samples did not reveal any transcripts for P190. We conclude that in some patients the appearance of P190BCR-ABL may correlate with transformation to a more aggressive, terminal phase of CML.
AB - The Philadelphia translocation in chronic myelogenous leukemia (CML) results in the production of a 210 kD BCR-ABL protein. In contrast, in 50% of Philadelphia-positive acute leukemias, the translocation results in the production of a 190 kD BCR-ABL protein. To investigate the hypothesis that the production of P190 may be associated with the progression from chronic phase to blast crisis in CML, we used polymerase chain reaction to analyze blood from 37 patients with accelerated phase/blast crisis CML for the transcripts coding for the P210BCR-ABL and P190BCR-ABL. The mRNA encoding for P210 was detected in all patients. In three patients, mRNA encoding both P210 and P190 was present. In two of these three patients, samples were available from the time of initial diagnosis. Analysis of these samples did not reveal any transcripts for P190. We conclude that in some patients the appearance of P190BCR-ABL may correlate with transformation to a more aggressive, terminal phase of CML.
UR - http://www.scopus.com/inward/record.url?scp=0025728842&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025728842&partnerID=8YFLogxK
M3 - Article
C2 - 2013978
AN - SCOPUS:0025728842
SN - 0887-6924
VL - 5
SP - 191
EP - 195
JO - Leukemia
JF - Leukemia
IS - 3
ER -