@article{de62d5526b2744b694cc39a0ffc7b4d3,
title = "Application of FISH 7q in MDS patients without monosomy 7 or 7q deletion by conventional G-banding cytogenetics: Does -7/7q- detection by FISH have prognostic value?",
abstract = "Chromosomal abnormalities are detected in 40-60% of patients with de novo myelodysplastic syndromes (MDS). This study used the FISH technique in 773 patients with de novo MDS without evidence of monosomy 7 (-7) or 7q deletion (7q-) by conventional G-banding cytogenetics (CC) to analyze their prognostic impact by FISH alone. FISH detected -7/7q- in 5.2% of patients. Presence of -7/7q- was associated with shorter overall survival than absence of such aberrations. Our results suggest that FISH 7q could be beneficial in patients with intermediate WHO morphologic risk stratification and no evidence of -7/7q- by CC.",
keywords = "Chromosome 7, Cytogenetics, FISH, MDS",
author = "Vera Adem{\`a} and Hern{\'a}ndez, {Jes{\'u}s Mar{\'i}a} and Mar{\'i}a Ab{\'a}igar and Eva Lumbreras and Esperanza Such and Anna Calull and Esther Dominguez and Leonor Arenillas and Mar Mallo and Jos{\'e} Cervera and Isabel Marug{\'a}n and Mar Tormo and Francisca Garc{\'i}a and Teresa Gonz{\'a}lez and Elisa Lu{\~n}o and Carmen Sanzo and Mart{\'i}n, {Mar{\'i}a Luisa} and Manuela Fern{\'a}ndez and Dolors Costa and Beatriz Bl{\'a}zquez and Beatriz Barre{\~n}a and Fernando Marco and Ana Batlle and Ismael Bu{\~n}o and Carolina Mart{\'i}nez-Laperche and V{\'i}ctor Noriega and Rosa Collado and David Ivars and F{\'e}lix Carbonell and Isabel Vallcorba and Josefa Melero and Elena Delgado and Vargas, {Mar{\'i}a Teresa} and Javier Grau and Marta Salido and Blanca Espinet and Carme Melero and Lourdes Florensa and Carmen Pedro and Francesc Sol{\'e}",
note = "Funding Information: Funding. This work was supported (in part) by a grant from the Instituto de Salud Carlos III, Ministerio de Sanidad y Consumo, Spain ( FI07/00107, CA08/00141, PI07/1009 and PI 11/02010 ); by the Red Tem{\'a}tica de Investigaci{\'o}n Cooperativa en C{\'a}ncer (RTICC, FEDER) ( RD06/0020/0031, RD07/0020/2004 and RD12/0036/0044 ); by the SGR 541 (Ag{\`e}ncia de Gesti{\'o} d{\textquoteright}Ajuts Universitaris i de Recerca, Departament d{\textquoteright}Innovaci{\'o}, Universitats i Empresa) , by the Proyectos de Investigaci{\'o}n del SACYL 355/A/09 ; Acci{\'o}n COST BM0801: European Genomics and Epigenomics Study on MDS and AML and MDS Celgene Spain. Editorial support for preparation of this manuscript was provided by Kate Unsworth of the Investigator Initiated Research Writing Group (part of the KnowledgePoint 360 Group), funded by Celgene Corporation, Global Scientific Communications, Summit, NJ . The authors directed development of the manuscript and were fully responsible for all content and editorial decisions for this manuscript. Statistical support for preparation of this manuscript was provided by Sergi Mojal of the Consulting service on methodology for biomedical research IMIM. ",
year = "2013",
month = apr,
doi = "10.1016/j.leukres.2012.12.010",
language = "English (US)",
volume = "37",
pages = "416--421",
journal = "Leukemia Research",
issn = "0145-2126",
publisher = "Elsevier Limited",
number = "4",
}