Abstract
Aromatase inhibitors (Als) have greatly enriched the treatment of hormone receptor-positive breast cancer in postmenopausal patients. Before the introduction of the well-tolerated third-generation Als, tamoxifen was the mainstay of endocrine therapy for hormone receptor-positive breast cancer. Many clinical trials have shown the superiority of Als compared with tamoxifen in adjuvant breast cancer treatment, as well as their benefit in metastatic breast cancer. NCCN guidelines recommendations for their use are based on the evidence provided by these clinical trials. This discussion reviews the evidence supporting the current guidelines for use of Al therapy in the treatment of hormone receptor-positive postmenopausal breast cancer patients.
Original language | English (US) |
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Pages (from-to) | 309-314 |
Number of pages | 6 |
Journal | JNCCN Journal of the National Comprehensive Cancer Network |
Volume | 3 |
Issue number | 3 |
DOIs | |
State | Published - May 2005 |
Keywords
- Aromatase inhibitor
- Breast cancer
- Postmenopausal
ASJC Scopus subject areas
- Oncology