TY - JOUR
T1 - Arterial spin-labeling perfusion imaging of childhood meningitis
T2 - a case series
AU - Wong, Alex Mun Ching
AU - Yeh, Chih Hua
AU - Liu, Ho Ling
AU - Lin, Kuang Lin
AU - Wang, Huei Shyong
AU - Toh, Cheng Hong
N1 - Publisher Copyright:
© 2015, Springer-Verlag Berlin Heidelberg.
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Introduction: Conventional magnetic resonance imaging (MRI), which is mainly used to detect complications, is ineffective in determining the neurological status of patients with meningitis. Hemodynamic change in the brain may be more indicative of the neurological status but few imaging studies have verified this. Arterial spin-labeling (ASL) perfusion, a noninvasive MR method requiring no contrast agent injection, can be used to measure cerebral blood flow (CBF). Case reports: We describe three pediatric patients with meningitis, who all showed regions of increased CBF on perfusion imaging. One patient, presenting with headache and conscious disturbance, had CBF changes in the frontal, temporal, and occipital regions. The other two patients, presenting with hallucinations, memory deficits, and seizures, had CBF changes in the frontal and temporal regions. Conclusion: ASL perfusion imaging may be helpful in assessing patients with meningitis, demonstrating CBF changes more strongly correlating with the neurological status, and detecting active brain abnormalities.
AB - Introduction: Conventional magnetic resonance imaging (MRI), which is mainly used to detect complications, is ineffective in determining the neurological status of patients with meningitis. Hemodynamic change in the brain may be more indicative of the neurological status but few imaging studies have verified this. Arterial spin-labeling (ASL) perfusion, a noninvasive MR method requiring no contrast agent injection, can be used to measure cerebral blood flow (CBF). Case reports: We describe three pediatric patients with meningitis, who all showed regions of increased CBF on perfusion imaging. One patient, presenting with headache and conscious disturbance, had CBF changes in the frontal, temporal, and occipital regions. The other two patients, presenting with hallucinations, memory deficits, and seizures, had CBF changes in the frontal and temporal regions. Conclusion: ASL perfusion imaging may be helpful in assessing patients with meningitis, demonstrating CBF changes more strongly correlating with the neurological status, and detecting active brain abnormalities.
KW - Arterial spin-labeling perfusion
KW - Cerebral blood flow
KW - Meningitis
UR - http://www.scopus.com/inward/record.url?scp=84959332008&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84959332008&partnerID=8YFLogxK
U2 - 10.1007/s00381-015-2858-4
DO - 10.1007/s00381-015-2858-4
M3 - Article
C2 - 26248672
AN - SCOPUS:84959332008
SN - 0256-7040
VL - 32
SP - 563
EP - 567
JO - Child's Nervous System
JF - Child's Nervous System
IS - 3
ER -