Arthritis Associated with Immune Checkpoint Inhibitors

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The development and approval of immune checkpoint inhibitors (ICIs) have dramatically improved the outcomes for many cancer patients. However, these agents have unique toxicities known as immune-related adverse events (irAEs), which result from unpredictable activation of the immune system against host organs. A wide myriad of musculoskeletal and rheumatologic irAEs have been reported, but inflammatory arthritis remains the most frequent. Here, we will highlight the current state of knowledge about the epidemiology, pathogenesis, salient clinical presentations, and treatment strategies of ICI-induced inflammatory arthritis.

Original languageEnglish (US)
Title of host publicationRare Diseases of the Immune System
PublisherSpringer Nature
Pages231-242
Number of pages12
DOIs
StatePublished - 2022

Publication series

NameRare Diseases of the Immune System
ISSN (Print)2282-6505
ISSN (Electronic)2283-6403

Keywords

  • Arthritis
  • Cancer
  • Immune checkpoint inhibitors
  • Immune-related adverse events

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Genetics(clinical)

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