Aryl hydrocarbon hydroxylase and tyrosine aminotransferase activities in somatic-cell hybrids derived from hepatoma tissue culture HTC (rat) cells and 3T3 (mouse) benzo[a]pyrene-resistant cells

E. Brad Thompson; W. F. Benedict; Ida S. Owens; D. W. Nebert

doi:10.1016/0006-291X(74)90647-0

Aryl hydrocarbon hydroxylase and tyrosine aminotransferase activities in somatic-cell hybrids derived from hepatoma tissue culture HTC (rat) cells and 3T3 (mouse) benzo[a]pyrene-resistant cells

E. Brad Thompson, W. F. Benedict, Ida S. Owens, D. W. Nebert

Genitourinary Medical Oncology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Somatic-cell hybrids were formed between a 3T3 (mouse) benzo[a]pyrene-resistant subline having very low basal or inducible aryl hydrocarbon hydroxylase and tyrosine aminotransferase activities and hepatoma tissue culture (rat) cells which lack the hydroxylase activity but contain the steroid-inducible aminotransferase. The benz[a]anthracene-inducible hydroxylase activity was absent or very low in all the hybrids. As has been the case in other hybrids from various parental lines, the aminotransferase was no longer inducible.

Original language	English (US)
Pages (from-to)	605-610
Number of pages	6
Journal	Biochemical and biophysical research communications
Volume	56
Issue number	3
DOIs	https://doi.org/10.1016/0006-291X(74)90647-0
State	Published - Feb 4 1974

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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Thompson, E. B., Benedict, W. F., Owens, I. S., & Nebert, D. W. (1974). Aryl hydrocarbon hydroxylase and tyrosine aminotransferase activities in somatic-cell hybrids derived from hepatoma tissue culture HTC (rat) cells and 3T3 (mouse) benzo[a]pyrene-resistant cells. Biochemical and biophysical research communications, 56(3), 605-610. https://doi.org/10.1016/0006-291X(74)90647-0

Aryl hydrocarbon hydroxylase and tyrosine aminotransferase activities in somatic-cell hybrids derived from hepatoma tissue culture HTC (rat) cells and 3T3 (mouse) benzo[a]pyrene-resistant cells. / Thompson, E. Brad; Benedict, W. F.; Owens, Ida S. et al.
In: Biochemical and biophysical research communications, Vol. 56, No. 3, 04.02.1974, p. 605-610.

Research output: Contribution to journal › Article › peer-review

Thompson, EB, Benedict, WF, Owens, IS & Nebert, DW 1974, 'Aryl hydrocarbon hydroxylase and tyrosine aminotransferase activities in somatic-cell hybrids derived from hepatoma tissue culture HTC (rat) cells and 3T3 (mouse) benzo[a]pyrene-resistant cells', Biochemical and biophysical research communications, vol. 56, no. 3, pp. 605-610. https://doi.org/10.1016/0006-291X(74)90647-0

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Aryl hydrocarbon hydroxylase and tyrosine aminotransferase activities in somatic-cell hybrids derived from hepatoma tissue culture HTC (rat) cells and 3T3 (mouse) benzo[a]pyrene-resistant cells

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