TY - JOUR
T1 - Asian over-representation among patients with hemifacial spasm compared to patients with cranial-cervical dystonia
AU - Wu, Yuncheng
AU - Davidson, Anthony L.
AU - Pan, Tianhong
AU - Jankovic, Joseph
N1 - Funding Information:
This work was supported by Diana Helis Henry Medical Research Foundation (2007–2010) and Carolyn Weiss Law seed funding, partially supported by NIH of the Clinical Center for the Study of Neuroprotection from PD ( 5U10NS044441-07 ). We also thank the National Parkinson Foundation of their support of the NPF Center of Excellence at Baylor College of Medicine. We are also thankful Rupesh Koshy for providing ethnic/race data for City of Houston as taken from the American Community Survey Estimate for the year 2008. We are also thankful Airong Wang for her providing statically analysis.
PY - 2010/11/15
Y1 - 2010/11/15
N2 - Background and purpose: Hemifacial spasm (HFS) is a common movement disorder, but its prevalence in different populations has not been elucidated. Methods: We reviewed all patients with HFS currently followed at the Baylor College of Medicine Movement Disorders Clinic and compared their demographic and clinical data with a control group of patients with cranial-cervical dystonia (CD). Results: In contrast to patients with CD (N = 145, mean age 48.64 ± 13.61 years), of whom 117 (80.69%) were Caucasians, 13 (8.97%) Hispanic, 10 (6.90%) African-American, and 5 (3.45%) were of Asian origin, there were 81 (61.36%) Caucasians, 24 (18.18%) Hispanic, 13 (9.85%) African-Americans, and 14 (10.61%) Asians in the HFS group (N = 132, mean age 49.33 ± 13.25). Although there was no statistical difference in the age and gender distribution between the two groups, the frequency of Asians in HFS group was 3.1 times higher than that in CD group (P < 0.01). Furthermore, the prevalence of Asians among patients with HFS was nearly twice the estimated prevalence of Asians in a general Houston population (5.48%). Conclusion: Our results support the observation that HFS is much more common in the Asian population than in other populations. Further epidemiological, genetic, imaging and anatomic studies are needed to understand the apparent difference in the prevalence of this peripherally induced movement disorder.
AB - Background and purpose: Hemifacial spasm (HFS) is a common movement disorder, but its prevalence in different populations has not been elucidated. Methods: We reviewed all patients with HFS currently followed at the Baylor College of Medicine Movement Disorders Clinic and compared their demographic and clinical data with a control group of patients with cranial-cervical dystonia (CD). Results: In contrast to patients with CD (N = 145, mean age 48.64 ± 13.61 years), of whom 117 (80.69%) were Caucasians, 13 (8.97%) Hispanic, 10 (6.90%) African-American, and 5 (3.45%) were of Asian origin, there were 81 (61.36%) Caucasians, 24 (18.18%) Hispanic, 13 (9.85%) African-Americans, and 14 (10.61%) Asians in the HFS group (N = 132, mean age 49.33 ± 13.25). Although there was no statistical difference in the age and gender distribution between the two groups, the frequency of Asians in HFS group was 3.1 times higher than that in CD group (P < 0.01). Furthermore, the prevalence of Asians among patients with HFS was nearly twice the estimated prevalence of Asians in a general Houston population (5.48%). Conclusion: Our results support the observation that HFS is much more common in the Asian population than in other populations. Further epidemiological, genetic, imaging and anatomic studies are needed to understand the apparent difference in the prevalence of this peripherally induced movement disorder.
KW - Asian
KW - Cranial dystonia
KW - Ethnicity race
KW - Hemifacial spasm
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U2 - 10.1016/j.jns.2010.08.017
DO - 10.1016/j.jns.2010.08.017
M3 - Article
C2 - 20864122
AN - SCOPUS:77958153300
SN - 0022-510X
VL - 298
SP - 61
EP - 63
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
IS - 1-2
ER -